Source: CURATED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 232 407
IL6 P05231 interleukin 6 0.32 0.248 0.962 270 4
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 167 4
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 95 5
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 179 27
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 141 11
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 98 61
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 124 58
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 130 54
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 182 355
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 138 9
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 109 1
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 109 7
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 239 0
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 119 12
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 115 90
PIK3CD O00329 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Kinase 1.00 0.319 0.885 9 9
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 164 35
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 138 40
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 80 3
PIK3CB P42338 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Kinase 1.00 0.322 0.885 11 1
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 113 95
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 89 2
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 101 18