Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
NLRP3 Q96P20 NLR family pyrin domain containing 3 8.1E-04 0.361 0.962 805 74
CAT P04040 catalase Enzyme 1.6E-10 0.359 0.962 794 14
SERPINE1 P05121 serpin family E member 1 Enzyme modulator 4.4E-02 0.359 0.885 770 23
MIR21 microRNA 21 0.363 0.846 726 2
FN1 P02751 fibronectin 1 Signaling 1.4E-03 0.365 0.962 724 33
HMGB1 P09429 high mobility group box 1 Nucleic acid binding 0.82 0.368 0.923 724 10
CTLA4 P16410 cytotoxic T-lymphocyte associated protein 4 0.94 0.369 0.923 722 24
REN P00797 renin Enzyme 2.4E-07 0.370 0.923 721 25
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 706 39
SOD1 P00441 superoxide dismutase 1 Enzyme 0.18 0.379 0.962 689 68
SLC2A1 P11166 solute carrier family 2 member 1 Transporter 0.99 0.388 0.808 687 76
GH1 P01241 growth hormone 1 Signaling 3.0E-02 0.373 0.923 686 27
ADIPOQ Q15848 adiponectin, C1Q and collagen domain containing 4.6E-09 0.376 0.885 679 45
EDN1 P05305 endothelin 1 Signaling 0.46 0.380 0.846 679 23
SIRT1 Q96EB6 sirtuin 1 Epigenetic regulator 8.7E-02 0.378 0.885 675 21
SOD2 P04179 superoxide dismutase 2 Enzyme 0.15 0.379 0.923 668 32
MPO P05164 myeloperoxidase Enzyme 7.1E-15 0.377 0.923 653 25
CXCL10 P02778 C-X-C motif chemokine ligand 10 Signaling 0.37 0.378 0.885 631 9
CXCL12 P48061 C-X-C motif chemokine ligand 12 0.12 0.379 0.846 626 21
MUC1 P15941 mucin 1, cell surface associated 1.9E-02 0.384 0.885 594 18
MBL2 P11226 mannose binding lectin 2 Receptor 2.7E-03 0.390 0.846 563 21
LGALS3 P17931 galectin 3 Signaling 2.3E-05 0.392 0.846 557 15
PTH P01270 parathyroid hormone 1.2E-02 0.397 0.846 528 10
CCN2 P29279 cellular communication network factor 2 Signaling 5.0E-04 0.399 0.846 518 2