Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 1011 29
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 999 26
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 994 8
CD274 Q9NZQ7 CD274 molecule Receptor 1.9E-02 0.324 0.923 990 7
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 983 56
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 979 70
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 972 97
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923 957 6
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 953 13
CSF2 P04141 colony stimulating factor 2 Signaling 0.83 0.330 0.962 951 4
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 942 62
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 935 11
IL1A P01583 interleukin 1 alpha 1.6E-04 0.333 0.962 932 19
IL4 P05112 interleukin 4 4.7E-03 0.332 0.962 926 22
IL2 P60568 interleukin 2 0.48 0.336 0.885 894 4
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 888 48
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 886 50
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 852 49
ABCB1 P08183 ATP binding cassette subfamily B member 1 Transporter 1.3E-05 0.344 0.885 839 55
HLA-DRB1 P01911 major histocompatibility complex, class II, DR beta 1 Immune response 1.1E-03 0.333 0.923 839 21
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 826 38
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 816 57
LEP P41159 leptin 0.46 0.349 0.846 807 13
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 805 39