Source: CGI

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
MET P08581 MET proto-oncogene, receptor tyrosine kinase Kinase 0.97 0.380 0.846 13
RB1 P06400 RB transcriptional corepressor 1 Nucleic acid binding 1.00 0.444 0.885 13
EP300 Q09472 E1A binding protein p300 1.00 0.459 0.846 12
KDM6A O15550 lysine demethylase 6A Epigenetic regulator 1.00 0.498 0.769 12
MLH1 P40692 mutL homolog 1 Nucleic acid binding 3.4E-05 0.399 0.808 12
POLE Q07864 DNA polymerase epsilon, catalytic subunit 8.0E-27 0.526 0.731 12
STAG2 Q8N3U4 stromal antigen 2 Nucleic acid binding 1.00 0.568 0.731 12
ALK Q9UM73 ALK receptor tyrosine kinase Kinase 3.2E-06 0.396 0.846 11
ERCC2 P18074 ERCC excision repair 2, TFIIH core complex helicase subunit Enzyme 7.1E-20 0.420 0.846 10
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 10
MAP2K1 Q02750 mitogen-activated protein kinase kinase 1 Kinase 0.90 0.439 0.846 10
PMS2 P54278 PMS1 homolog 2, mismatch repair system component Nucleic acid binding 4.5E-27 0.484 0.808 10
RNF43 Q68DV7 ring finger protein 43 0.73 0.584 0.577 10
CUX1 P39880 Q13948 cut like homeobox 1 Transcription factor 1.00 0.465 0.846 9
FGFR1 P11362 fibroblast growth factor receptor 1 Kinase 1.00 0.362 0.885 9
IDH1 O75874 isocitrate dehydrogenase (NADP(+)) 1 2.6E-12 0.424 0.808 9
MAP2K4 P45985 mitogen-activated protein kinase kinase 4 Kinase 1.00 0.559 0.692 9
MDM4 O15151 MDM4 regulator of p53 Nucleic acid binding 1.00 0.461 0.808 9
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 9
RET P07949 ret proto-oncogene Kinase 1.00 0.392 0.885 9
TBL1XR1 Q9BZK7 TBL1X receptor 1 1.00 0.534 0.808 9
AXIN1 O15169 axin 1 0.41 0.559 0.577 8
AXIN2 Q9Y2T1 axin 2 0.57 0.507 0.692 8
CDKN1B P46527 cyclin dependent kinase inhibitor 1B 0.62 0.409 0.769 8