Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 703 681
SOD1 P00441 superoxide dismutase 1 Enzyme 0.18 0.379 0.962 689 68
RAC1 P63000 Rac family small GTPase 1 Enzyme modulator 0.76 0.429 0.962 415 20
FCGR3A P08637 Fc fragment of IgG receptor IIIa Cell adhesion 3.7E-06 0.432 0.962 352 11
FCGR3B O75015 Fc fragment of IgG receptor IIIb Cell adhesion 3.0E-07 0.452 0.962 291 8
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 1899 59
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 1679 21
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 1511 83
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 1349 384
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 1337 31
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 1213 54
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 1193 57
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923 1110 39
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 1082 82
IL17A Q16552 interleukin 17A 4.3E-02 0.324 0.923 1074 19
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 1059 13
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 1044 15
SMUG1 Q53HV7 single-strand-selective monofunctional uracil-DNA glycosylase 1 4.5E-04 0.322 0.923 1034 6
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 1021 43
HLA-DRB1 P01911 major histocompatibility complex, class II, DR beta 1 Immune response 1.1E-03 0.333 0.923 1018 185
CD274 Q9NZQ7 CD274 molecule Receptor 1.9E-02 0.324 0.923 1011 8
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 995 85
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 992 56
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923 859 12