Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 340 9
SOD2 P04179 superoxide dismutase 2 Enzyme 0.15 0.379 0.923 285 1
IL6 P05231 interleukin 6 0.32 0.248 0.962 270 4
POMC P01189 proopiomelanocortin 1.2E-04 0.356 0.846 241 7
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 231 5
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 192 93
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 179 27
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 167 4
IFNG P01579 interferon gamma 0.47 0.288 0.962 167 1
INS P01308 insulin 0.30 0.445 0.923 157 34
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923 146 14
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 141 11
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 138 9
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 138 5
DRD2 P14416 dopamine receptor D2 G-protein coupled receptor 0.75 0.436 0.846 133 7
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 119 20
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 119 12
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 115 30
CNR1 P21554 cannabinoid receptor 1 G-protein coupled receptor 0.51 0.446 0.808 115 1
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 113 95
PON1 P27169 paraoxonase 1 9.8E-11 0.409 0.885 112 15
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 109 7
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 109 1
BCHE P06276 butyrylcholinesterase 1.1E-13 0.447 0.923 108 98