Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 1349 384
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 1250 33
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 1228 107
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 1213 54
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 1206 36
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923 1110 39
PIK3CB P42338 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Kinase 1.00 0.322 0.885 1083 13
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 992 56
COX2 P00403 cytochrome c oxidase subunit II Enzyme 0.352 0.962 875 79
LMNA P02545 lamin A/C 1.00 0.384 0.885 824 285
FGFR1 P11362 fibroblast growth factor receptor 1 Kinase 1.00 0.362 0.885 816 119
TP63 Q9H3D4 tumor protein p63 Transcription factor 1.00 0.362 0.769 816 64
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923 747 2600
FGFR2 P21802 fibroblast growth factor receptor 2 Kinase 1.00 0.380 0.808 731 141
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 703 681
PTPN11 Q06124 protein tyrosine phosphatase non-receptor type 11 1.00 0.385 0.923 702 98
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 698 29
EDN1 P05305 endothelin 1 Signaling 0.46 0.380 0.846 679 23
MECP2 P51608 methyl-CpG binding protein 2 Epigenetic regulator 0.89 0.414 0.846 664 387
BRCA2 P51587 BRCA2 DNA repair associated Nucleic acid binding 2.4E-25 0.379 0.846 656 3066
FGFR3 P22607 fibroblast growth factor receptor 3 Kinase 1.6E-05 0.391 0.846 654 55
COMT P21964 catechol-O-methyltransferase Enzyme 1.1E-06 0.400 0.923 622 47
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 611 17
SMAD4 Q13485 SMAD family member 4 Transcription factor 1.00 0.401 0.808 575 144