Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 45
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 28
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 27
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 20
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885 20
BRCA2 P51587 BRCA2 DNA repair associated Nucleic acid binding 2.4E-25 0.379 0.846 16
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923 14
AXIN1 O15169 axin 1 0.41 0.559 0.577 8
KLF6 Q99612 Kruppel like factor 6 Nucleic acid binding 0.98 0.501 0.846 8
PALB2 Q86YC2 partner and localizer of BRCA2 3.0E-19 0.485 0.769 8
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 6
CHEK2 O96017 checkpoint kinase 2 Kinase 1.2E-24 0.460 0.808 5
FOXA1 P55317 forkhead box A1 Transcription factor 0.22 0.522 0.731 5
SPOP O43791 speckle type BTB/POZ protein 1.00 0.597 0.500 4
FANCA O15360 FA complementation group A 1.6E-68 0.505 0.731 3
AURKA O14965 aurora kinase A Kinase 0.87 0.475 0.731 2
MAD1L1 Q9Y6D9 mitotic arrest deficient 1 like 1 6.8E-16 0.570 0.731 2
AR P10275 androgen receptor Nuclear receptor 0.99 0.351 0.846 1
EPHB2 P29323 EPH receptor B2 Kinase 1.00 0.374 0.846 1
HDAC2 Q92769 histone deacetylase 2 Epigenetic regulator 1.00 0.476 0.846 1