Source: RGD

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 86
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 82
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 76
HMOX1 P09601 heme oxygenase 1 9.7E-03 0.381 0.923 69
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 69
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 60
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 58
EDN1 P05305 endothelin 1 Signaling 0.46 0.380 0.846 48
SERPINE1 P05121 serpin family E member 1 Enzyme modulator 4.4E-02 0.359 0.885 48
FAS P25445 Fas cell surface death receptor 0.81 0.372 0.923 45
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 45
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 45
NOS1 P29475 nitric oxide synthase 1 1.00 0.408 0.885 44
AGER Q15109 advanced glycosylation end-product specific receptor Receptor 6.4E-16 0.420 0.885 43
CAT P04040 catalase Enzyme 1.6E-10 0.359 0.962 41
IL18 Q14116 interleukin 18 3.1E-02 0.365 0.923 40
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 40
BECN1 Q14457 beclin 1 Enzyme modulator 0.94 0.432 0.846 39
C3 P01024 complement C3 Enzyme modulator 0.90 0.445 0.885 33
ANXA1 P04083 annexin A1 1.2E-07 0.442 0.885 30
BAD Q92934 BCL2 associated agonist of cell death 4.6E-03 0.553 0.769 30
GJA1 P17302 gap junction protein alpha 1 Cell-cell junction 0.16 0.393 0.885 27
IL17A Q16552 interleukin 17A 4.3E-02 0.324 0.923 27
CCR5 P51681 C-C motif chemokine receptor 5 (gene/pseudogene) G-protein coupled receptor 4.3E-10 0.398 0.885 26