Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 101
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 94
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 92
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 86
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 72
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 62
CASP3 P42574 caspase 3 Enzyme 0.10 0.351 0.923 62
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 59
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 58
ICAM1 P05362 intercellular adhesion molecule 1 3.5E-02 0.364 0.962 55
FAS P25445 Fas cell surface death receptor 0.81 0.372 0.923 49
SERPINE1 P05121 serpin family E member 1 Enzyme modulator 4.4E-02 0.359 0.885 48
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 47
NOS1 P29475 nitric oxide synthase 1 1.00 0.408 0.885 46
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 45
BAX Q07812 BCL2 associated X, apoptosis regulator Signaling 0.32 0.417 0.885 44
AGER Q15109 advanced glycosylation end-product specific receptor Receptor 6.4E-16 0.420 0.885 43
BECN1 Q14457 beclin 1 Enzyme modulator 0.94 0.432 0.846 40
NQO1 P15559 NAD(P)H quinone dehydrogenase 1 1.2E-09 0.434 0.885 40
MFN2 O95140 mitofusin 2 Enzyme 0.99 0.471 0.846 38
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 38
CASP9 P55211 caspase 9 Enzyme 7.4E-06 0.458 0.808 37
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 37
CASP8 Q14790 caspase 8 Enzyme 3.7E-06 0.404 0.923 35