Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 226
IL6 P05231 interleukin 6 0.32 0.248 0.962 177
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 169
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 134
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 118
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 100
IFNG P01579 interferon gamma 0.47 0.288 0.962 91
ICAM1 P05362 intercellular adhesion molecule 1 3.5E-02 0.364 0.962 89
HLA-DRB1 P01911 major histocompatibility complex, class II, DR beta 1 Immune response 1.1E-03 0.333 0.923 88
CRP P02741 C-reactive protein 3.7E-03 0.299 0.962 85
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 84
IL18 Q14116 interleukin 18 3.1E-02 0.365 0.923 83
IL4 P05112 interleukin 4 4.7E-03 0.332 0.962 67
TIMP1 P01033 TIMP metallopeptidase inhibitor 1 Enzyme modulator 0.50 0.380 0.885 64
IL1RN P18510 interleukin 1 receptor antagonist 3.1E-02 0.373 0.923 55
CTLA4 P16410 cytotoxic T-lymphocyte associated protein 4 0.94 0.369 0.923 53
MBL2 P11226 mannose binding lectin 2 Receptor 2.7E-03 0.390 0.846 53
MMP3 P08254 matrix metallopeptidase 3 Enzyme 5.7E-15 0.408 0.885 52
PON1 P27169 paraoxonase 1 9.8E-11 0.409 0.885 52
SPP1 P10451 secreted phosphoprotein 1 2.1E-06 0.353 0.885 50
ABCB1 P08183 ATP binding cassette subfamily B member 1 Transporter 1.3E-05 0.344 0.885 49
CCL5 P13501 C-C motif chemokine ligand 5 Signaling 1.8E-03 0.403 0.885 49
MMP1 P03956 matrix metallopeptidase 1 Enzyme 7.7E-18 0.385 0.885 48
CD44 P16070 CD44 molecule (Indian blood group) 2.4E-07 0.363 0.962 47