Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 138
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 101
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 94
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 86
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 72
HMOX1 P09601 heme oxygenase 1 9.7E-03 0.381 0.923 71
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 64
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 62
CASP3 P42574 caspase 3 Enzyme 0.10 0.351 0.923 62
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 59
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 58
IL6 P05231 interleukin 6 0.32 0.248 0.962 54
FAS P25445 Fas cell surface death receptor 0.81 0.372 0.923 49
EDN1 P05305 endothelin 1 Signaling 0.46 0.380 0.846 48
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 47
NOS1 P29475 nitric oxide synthase 1 1.00 0.408 0.885 46
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 45
BAX Q07812 BCL2 associated X, apoptosis regulator Signaling 0.32 0.417 0.885 44
PPARGC1A Q9UBK2 PPARG coactivator 1 alpha Transcription factor 1.00 0.453 0.885 42
BECN1 Q14457 beclin 1 Enzyme modulator 0.94 0.432 0.846 40
AGTR1 P30556 angiotensin II receptor type 1 G-protein coupled receptor 5.3E-04 0.423 0.846 34
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923 32
SOD2 P04179 superoxide dismutase 2 Enzyme 0.15 0.379 0.923 31
HP P00738 haptoglobin Enzyme 1.7E-05 0.412 0.885 30