Source: LHGDN

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 226
IL6 P05231 interleukin 6 0.32 0.248 0.962 177
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 171
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 169
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 149
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 134
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 110
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 100
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 95
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 94
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 86
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 84
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 83
IL18 Q14116 interleukin 18 3.1E-02 0.365 0.923 83
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 77
FAS P25445 Fas cell surface death receptor 0.81 0.372 0.923 76
NFKB1 P19838 nuclear factor kappa B subunit 1 Transcription factor 1.00 0.396 0.923 72
IL4 P05112 interleukin 4 4.7E-03 0.332 0.962 67
FASLG P48023 Fas ligand Signaling 0.18 0.430 0.885 66
TERT O14746 telomerase reverse transcriptase Enzyme 0.99 0.374 0.846 66
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 64
GSTM1 P09488 glutathione S-transferase mu 1 2.1E-03 0.380 0.923 62
VDR P11473 vitamin D receptor Nuclear receptor 1.7E-05 0.352 0.885 61
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 60