Source: CGI

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 39
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 33
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 29
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 17
KIT P10721 KIT proto-oncogene, receptor tyrosine kinase Kinase 0.98 0.366 0.808 16
NOTCH2 Q04721 notch receptor 2 1.00 0.441 0.808 15
EP300 Q09472 E1A binding protein p300 1.00 0.459 0.846 12
CUX1 P39880 Q13948 cut like homeobox 1 Transcription factor 1.00 0.465 0.846 9
IDH1 O75874 isocitrate dehydrogenase (NADP(+)) 1 2.6E-12 0.424 0.808 9
FANCC Q00597 FA complementation group C 2.8E-13 0.507 0.808 8
PALB2 Q86YC2 partner and localizer of BRCA2 3.0E-19 0.485 0.769 8
RAD21 O60216 RAD21 cohesin complex component 1.00 0.528 0.846 8
CSF3R Q99062 colony stimulating factor 3 receptor Signaling 1.5E-10 0.550 0.692 7
JAK2 O60674 Janus kinase 2 Kinase 0.65 0.385 0.885 7
BRIP1 Q9BX63 BRCA1 interacting protein C-terminal helicase 1 Enzyme 6.2E-17 0.507 0.731 6
SETBP1 Q9Y6X0 SET binding protein 1 1.00 0.503 0.808 6
IDH2 P48735 isocitrate dehydrogenase (NADP(+)) 2 0.88 0.434 0.808 5
SH2B3 Q9UQQ2 SH2B adaptor protein 3 1.0E-04 0.527 0.692 5
CBL P22681 Cbl proto-oncogene Enzyme 6.1E-04 0.527 0.769 4
CREBBP Q92793 CREB binding protein 1.00 0.428 0.808 4
ARHGAP26 Q9UNA1 Rho GTPase activating protein 26 Enzyme modulator 1.00 0.656 0.500 3
FANCA O15360 FA complementation group A 1.6E-68 0.505 0.731 3
JAK1 P23458 Janus kinase 1 Kinase 1.00 0.474 0.769 3
NPM1 P06748 nucleophosmin 1 Chaperone 1.00 0.464 0.846 3