Source: CLINVAR

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
PTPN11 Q06124 protein tyrosine phosphatase non-receptor type 11 1.00 0.385 0.923 153 73
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 84 390
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 71 21
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 66 35
NSD1 Q96L73 nuclear receptor binding SET domain protein 1 Epigenetic regulator 1.00 0.505 0.769 54 237
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 37 14
KIT P10721 KIT proto-oncogene, receptor tyrosine kinase Kinase 0.98 0.366 0.808 21 66
WT1 P19544 WT1 transcription factor Nucleic acid binding 1.00 0.422 0.808 20 38
IDH1 O75874 isocitrate dehydrogenase (NADP(+)) 1 2.6E-12 0.424 0.808 18 2
DNMT3A Q9Y6K1 DNA methyltransferase 3 alpha 7.4E-39 0.445 0.846 14 22
JAK2 O60674 Janus kinase 2 Kinase 0.65 0.385 0.885 12 8
DNAJC21 Q5F1R6 DnaJ heat shock protein family (Hsp40) member C21 2.1E-07 0.606 0.731 9 7
IDH2 P48735 isocitrate dehydrogenase (NADP(+)) 2 0.88 0.434 0.808 9 5
SF3B2 Q13435 splicing factor 3b subunit 2 1.00 0.780 0.308 9 2
U2AF1 P0DN76 Q01081 U2 small nuclear RNA auxiliary factor 1 Nucleic acid binding 0.99 0.604 0.577 9 2
SF3B1 O75533 splicing factor 3b subunit 1 Nucleic acid binding 1.00 0.511 0.731 8 9
RUNX1 Q01196 RUNX family transcription factor 1 Transcription factor 0.65 0.425 0.808 7 23
ETV6 P41212 ETS variant transcription factor 6 Transcription factor 0.97 0.477 0.731 6 9
GATA2 P23769 GATA binding protein 2 0.98 0.496 0.654 5 25
CSF3R Q99062 colony stimulating factor 3 receptor Signaling 1.5E-10 0.550 0.692 5 10
JAK1 P23458 Janus kinase 1 Kinase 1.00 0.474 0.769 5 3
TEK Q02763 TEK receptor tyrosine kinase Kinase 1.00 0.462 0.692 3 6
FLT3 P36888 fms related receptor tyrosine kinase 3 Kinase 0.61 0.462 0.654 2 29
DDX41 Q9UJV9 DEAD-box helicase 41 5.6E-08 0.636 0.538 2 10