Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
SLC6A4 P31645 solute carrier family 6 member 4 Transporter 0.25 0.429 0.808 26
DRD2 P14416 dopamine receptor D2 G-protein coupled receptor 0.75 0.436 0.846 16
COMT P21964 catechol-O-methyltransferase Enzyme 1.1E-06 0.400 0.923 15
DRD4 P21917 dopamine receptor D4 G-protein coupled receptor 9.3E-09 0.517 0.577 13
PDYN P01213 prodynorphin Signaling 1.7E-04 0.535 0.577 11
NCAM1 P13591 neural cell adhesion molecule 1 1.00 0.415 0.885 10
CNR2 P34972 cannabinoid receptor 2 G-protein coupled receptor 6.5E-06 0.509 0.846 8
GAL P22466 galanin and GMAP prepropeptide 4.4E-06 0.493 0.846 8
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 7
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 7
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 7
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 5
HCRT O43612 hypocretin neuropeptide precursor 2.9E-02 0.500 0.808 5
MAPK14 Q16539 mitogen-activated protein kinase 14 Kinase 0.37 0.379 0.923 5
NRG1 Q02297 neuregulin 1 Signaling 1.00 0.464 0.885 5
PENK P01210 proenkephalin Signaling 2.1E-04 0.560 0.808 4
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 3
CHRM5 P08912 cholinergic receptor muscarinic 5 G-protein coupled receptor 4.0E-03 0.769 0.346 2
FAAH O00519 fatty acid amide hydrolase 4.4E-11 0.545 0.692 2
RGS17 Q9UGC6 regulator of G protein signaling 17 Enzyme modulator 0.27 0.716 0.346 1