Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 45
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 39
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 33
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 29
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 27
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 23
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 20
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 17
STK11 Q15831 serine/threonine kinase 11 Kinase 0.99 0.435 0.808 17
KIT P10721 KIT proto-oncogene, receptor tyrosine kinase Kinase 0.98 0.366 0.808 16
BAP1 Q92560 BRCA1 associated protein 1 Enzyme 0.99 0.454 0.731 14
STAG2 Q8N3U4 stromal antigen 2 Nucleic acid binding 1.00 0.568 0.731 12
ALK Q9UM73 ALK receptor tyrosine kinase Kinase 3.2E-06 0.396 0.846 11
ERCC2 P18074 ERCC excision repair 2, TFIIH core complex helicase subunit Enzyme 7.1E-20 0.420 0.846 10
MAP2K1 Q02750 mitogen-activated protein kinase kinase 1 Kinase 0.90 0.439 0.846 10
CUX1 P39880 Q13948 cut like homeobox 1 Transcription factor 1.00 0.465 0.846 9
RET P07949 ret proto-oncogene Kinase 1.00 0.392 0.885 9
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 8
ERCC4 Q92889 ERCC excision repair 4, endonuclease catalytic subunit Enzyme 1.4E-12 0.468 0.846 8
NF1 P21359 neurofibromin 1 Enzyme modulator 0.90 0.440 0.885 8
ERBB4 Q15303 erb-b2 receptor tyrosine kinase 4 Kinase 1.00 0.455 0.846 6
CDK4 P11802 cyclin dependent kinase 4 Kinase 6.3E-02 0.412 0.808 5
PDGFRA P16234 platelet derived growth factor receptor alpha Kinase 1.00 0.415 0.808 5
DDB2 Q92466 damage specific DNA binding protein 2 Nucleic acid binding 7.4E-06 0.576 0.654 4