Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 13 33
STK11 Q15831 serine/threonine kinase 11 Kinase 0.99 0.435 0.808 12 18
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 10 34
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 10 32
BRCA2 P51587 BRCA2 DNA repair associated Nucleic acid binding 2.4E-25 0.379 0.846 8 78
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 5 12
NF2 P35240 neurofibromin 2 1.00 0.468 0.885 4 7
AKT3 Q9Y243 AKT serine/threonine kinase 3 Kinase 1.00 0.512 0.808 3 4
ABL1 P00519 ABL proto-oncogene 1, non-receptor tyrosine kinase Kinase 1.00 0.432 0.923 3 2
ACVR1 Q04771 activin A receptor type 1 Kinase 0.33 0.535 0.731 2 6
UBR4 Q5T4S7 ubiquitin protein ligase E3 component n-recognin 4 1.00 0.760 0.269 2 1
MYO1B O43795 myosin IB Cellular structure 7.2E-05 0.691 0.538 2 0
TRAPPC1 Q9Y5R8 trafficking protein particle complex 1 Transporter 8.7E-02 0.931 0.115 1 1