Source: INFERRED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
LMNA P02545 lamin A/C 1.00 0.384 0.885 468
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 382
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 342
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 341
FGFR1 P11362 fibroblast growth factor receptor 1 Kinase 1.00 0.362 0.885 330
FBN1 P35555 fibrillin 1 Calcium-binding protein 1.00 0.417 0.846 327
MECP2 P51608 methyl-CpG binding protein 2 Epigenetic regulator 0.89 0.414 0.846 326
COL2A1 P02458 collagen type II alpha 1 chain 1.00 0.444 0.846 325
FGFR3 P22607 fibroblast growth factor receptor 3 Kinase 1.6E-05 0.391 0.846 307
PTPN11 Q06124 protein tyrosine phosphatase non-receptor type 11 1.00 0.385 0.923 286
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 283
CHD7 Q9P2D1 chromodomain helicase DNA binding protein 7 1.00 0.441 0.846 281
POLG P54098 DNA polymerase gamma, catalytic subunit Enzyme 2.1E-09 0.457 0.846 279
PTCH1 Q13635 patched 1 1.00 0.398 0.885 262
ELN P15502 elastin 2.1E-14 0.415 0.885 257
ATRX P46100 ATRX chromatin remodeler 1.00 0.452 0.808 236
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 229
OFD1 O75665 OFD1 centriole and centriolar satellite protein 0.96 0.510 0.808 225
GJA1 P17302 gap junction protein alpha 1 Cell-cell junction 0.16 0.393 0.885 224
ATXN2 Q99700 ataxin 2 Nucleic acid binding 0.85 0.482 0.808 221
ERCC2 P18074 ERCC excision repair 2, TFIIH core complex helicase subunit Enzyme 7.1E-20 0.420 0.846 220
GBA P04062 glucosylceramidase beta 1.4E-06 0.500 0.808 220
BRCA2 P51587 BRCA2 DNA repair associated Nucleic acid binding 2.4E-25 0.379 0.846 218
COL1A1 P02452 collagen type I alpha 1 chain 1.00 0.430 0.808 218