Source: CTD_human

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 334
SOD2 P04179 superoxide dismutase 2 Enzyme 0.15 0.379 0.923 280
IL6 P05231 interleukin 6 0.32 0.248 0.962 262
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 234
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 185
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 178
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 170
CAT P04040 catalase Enzyme 1.6E-10 0.359 0.962 169
CSF3 P09919 colony stimulating factor 3 0.38 0.377 0.885 168
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 160
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 145
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 133
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 128
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 127
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 111
PLAU P00749 plasminogen activator, urokinase Enzyme 2.3E-06 0.425 0.923 109
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 105
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 99
AHR P35869 aryl hydrocarbon receptor Transcription factor 1.00 0.410 0.923 97
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 97
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 96
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 90
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 86
SIRT1 Q96EB6 sirtuin 1 Epigenetic regulator 8.7E-02 0.378 0.885 85