Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 1368 68
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 1349 384
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 1250 33
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 1228 107
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 1213 54
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 960 48
FGFR1 P11362 fibroblast growth factor receptor 1 Kinase 1.00 0.362 0.885 816 119
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923 747 2600
FGFR2 P21802 fibroblast growth factor receptor 2 Kinase 1.00 0.380 0.808 731 141
PTPN11 Q06124 protein tyrosine phosphatase non-receptor type 11 1.00 0.385 0.923 702 98
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 698 29
NOTCH1 P46531 notch receptor 1 1.00 0.369 0.885 693 64
SLC2A1 P11166 solute carrier family 2 member 1 Transporter 0.99 0.388 0.808 687 76
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885 684 974
MECP2 P51608 methyl-CpG binding protein 2 Epigenetic regulator 0.89 0.414 0.846 664 387
GJA1 P17302 gap junction protein alpha 1 Cell-cell junction 0.16 0.393 0.885 662 37
BRCA2 P51587 BRCA2 DNA repair associated Nucleic acid binding 2.4E-25 0.379 0.846 656 3066
FGFR3 P22607 fibroblast growth factor receptor 3 Kinase 1.6E-05 0.391 0.846 654 55
EZH2 Q15910 enhancer of zeste 2 polycomb repressive complex 2 subunit Epigenetic regulator 1.00 0.376 0.885 653 35
COMT P21964 catechol-O-methyltransferase Enzyme 1.1E-06 0.400 0.923 622 47
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 611 17
RET P07949 ret proto-oncogene Kinase 1.00 0.392 0.885 607 162
PTCH1 Q13635 patched 1 1.00 0.398 0.885 604 194
PRKAR1A P10644 protein kinase cAMP-dependent type I regulatory subunit alpha 1.00 0.401 0.846 597 65