Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 340 9
IL6 P05231 interleukin 6 0.32 0.248 0.962 270 4
POMC P01189 proopiomelanocortin 1.2E-04 0.356 0.846 241 7
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 239 0
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 231 5
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 192 93
CAT P04040 catalase Enzyme 1.6E-10 0.359 0.962 171 2
IFNA2 P01563 interferon alpha 2 0.442 0.885 170 0
CSF3 P09919 colony stimulating factor 3 0.38 0.377 0.885 168 2
IFNG P01579 interferon gamma 0.47 0.288 0.962 167 1
INS P01308 insulin 0.30 0.445 0.923 157 34
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 151 0
SOD1 P00441 superoxide dismutase 1 Enzyme 0.18 0.379 0.962 147 48
DRD2 P14416 dopamine receptor D2 G-protein coupled receptor 0.75 0.436 0.846 133 7
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 124 58
ALB P02768 albumin Transporter 0.64 0.317 0.962 123 9
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 119 20
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 115 105
CNR1 P21554 cannabinoid receptor 1 G-protein coupled receptor 0.51 0.446 0.808 115 1
PON1 P27169 paraoxonase 1 9.8E-11 0.409 0.885 112 15
OXT P01178 oxytocin/neurophysin I prepropeptide Signaling 0.71 0.615 0.423 110 1
NPY P01303 neuropeptide Y Signaling 0.14 0.447 0.846 109 0
CRH P06850 corticotropin releasing hormone Signaling 0.72 0.439 0.808 107 2
PDYN P01213 prodynorphin Signaling 1.7E-04 0.535 0.577 102 7