Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 101
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 94
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 92
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 86
HMOX1 P09601 heme oxygenase 1 9.7E-03 0.381 0.923 71
CASP3 P42574 caspase 3 Enzyme 0.10 0.351 0.923 62
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 59
ICAM1 P05362 intercellular adhesion molecule 1 3.5E-02 0.364 0.962 55
IL6 P05231 interleukin 6 0.32 0.248 0.962 54
FAS P25445 Fas cell surface death receptor 0.81 0.372 0.923 49
SERPINE1 P05121 serpin family E member 1 Enzyme modulator 4.4E-02 0.359 0.885 48
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 44
PPARGC1A Q9UBK2 PPARG coactivator 1 alpha Transcription factor 1.00 0.453 0.885 42
CAT P04040 catalase Enzyme 1.6E-10 0.359 0.962 41
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 41
CCL5 P13501 C-C motif chemokine ligand 5 Signaling 1.8E-03 0.403 0.885 40
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 35
CASP8 Q14790 caspase 8 Enzyme 3.7E-06 0.404 0.923 35
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 34
C3 P01024 complement C3 Enzyme modulator 0.90 0.445 0.885 34
PLAU P00749 plasminogen activator, urokinase Enzyme 2.3E-06 0.425 0.923 34
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923 32
CX3CR1 P49238 C-X3-C motif chemokine receptor 1 G-protein coupled receptor 6.1E-02 0.457 0.885 27
GSK3B P49841 glycogen synthase kinase 3 beta Kinase 0.96 0.430 0.846 26