Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 1511 83
TP63 Q9H3D4 tumor protein p63 Transcription factor 1.00 0.362 0.769 816 64
FGFR2 P21802 fibroblast growth factor receptor 2 Kinase 1.00 0.380 0.808 731 141
FGFR3 P22607 fibroblast growth factor receptor 3 Kinase 1.6E-05 0.391 0.846 654 55
SMAD4 Q13485 SMAD family member 4 Transcription factor 1.00 0.401 0.808 575 144
TWIST1 Q15672 twist family bHLH transcription factor 1 Transcription factor 0.34 0.397 0.846 559 31
KMT2A Q03164 lysine methyltransferase 2A 1.00 0.410 0.885 535 65
BMP2 P12643 bone morphogenetic protein 2 Signaling 0.99 0.432 0.846 428 12
EDNRA P25101 endothelin receptor type A G-protein coupled receptor 0.99 0.426 0.885 427 29
CHD7 Q9P2D1 chromodomain helicase DNA binding protein 7 1.00 0.441 0.846 419 247
ATRX P46100 ATRX chromatin remodeler 1.00 0.452 0.808 412 38
GLI3 P10071 GLI family zinc finger 3 1.00 0.436 0.846 400 73
MED12 Q93074 mediator complex subunit 12 Transcription factor 1.00 0.476 0.769 340 21
ATR Q13535 ATR serine/threonine kinase Kinase 3.5E-09 0.456 0.923 321 38
KMT2D O14686 lysine methyltransferase 2D 1.00 0.465 0.808 320 266
GBA P04062 glucosylceramidase beta 1.4E-06 0.500 0.808 319 157
ASXL1 Q8IXJ9 ASXL transcriptional regulator 1 1.3E-14 0.482 0.808 296 24
ZMPSTE24 O75844 zinc metallopeptidase STE24 Enzyme 8.9E-16 0.517 0.731 265 11
GATA1 P15976 GATA binding protein 1 0.95 0.483 0.808 264 19
RPS19 P39019 ribosomal protein S19 Nucleic acid binding 0.92 0.480 0.846 256 17
SKI P12755 SKI proto-oncogene 1.00 0.503 0.808 255 22
TFAP2A P05549 transcription factor AP-2 alpha Transcription factor 0.99 0.488 0.769 250 20
FKRP Q9H9S5 fukutin related protein 9.8E-06 0.513 0.731 248 71
KDM6A O15550 lysine demethylase 6A Epigenetic regulator 1.00 0.498 0.769 238 22