Source: RGD

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 76
CASP3 P42574 caspase 3 Enzyme 0.10 0.351 0.923 62
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 58
FAS P25445 Fas cell surface death receptor 0.81 0.372 0.923 45
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 45
XDH P47989 xanthine dehydrogenase Enzyme 2.6E-22 0.529 0.846 38
CASP9 P55211 caspase 9 Enzyme 7.4E-06 0.458 0.808 37
C3 P01024 complement C3 Enzyme modulator 0.90 0.445 0.885 33
CASP8 Q14790 caspase 8 Enzyme 3.7E-06 0.404 0.923 31
G6PD P11413 glucose-6-phosphate dehydrogenase Enzyme 0.97 0.424 0.846 31
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 28
MET P08581 MET proto-oncogene, receptor tyrosine kinase Kinase 0.97 0.380 0.846 26
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 25
HAMP P81172 hepcidin antimicrobial peptide 8.2E-03 0.433 0.846 24
IGF2 P01344 insulin like growth factor 2 4.4E-02 0.390 0.885 23
CTSB P07858 cathepsin B Enzyme 5.9E-11 0.457 0.846 22
INSR P06213 insulin receptor Kinase 3.6E-05 0.432 0.846 21
A2M P01023 alpha-2-macroglobulin Enzyme modulator 4.5E-11 0.529 0.769 20
ABCB1 P08183 ATP binding cassette subfamily B member 1 Transporter 1.3E-05 0.344 0.885 20
ABCC3 O15438 ATP binding cassette subfamily C member 3 Transporter 1.2E-26 0.517 0.769 20
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 20
EP300 Q09472 E1A binding protein p300 1.00 0.459 0.846 20
DNMT1 P26358 DNA methyltransferase 1 Epigenetic regulator 1.00 0.406 0.885 18
GJB2 P29033 gap junction protein beta 2 Cell-cell junction 6.6E-16 0.441 0.846 18