Source: RGD

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 92
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 90
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 86
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 82
CASP3 P42574 caspase 3 Enzyme 0.10 0.351 0.923 62
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 59
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 58
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 58
ICAM1 P05362 intercellular adhesion molecule 1 3.5E-02 0.364 0.962 54
IL6 P05231 interleukin 6 0.32 0.248 0.962 54
EDN1 P05305 endothelin 1 Signaling 0.46 0.380 0.846 48
SERPINE1 P05121 serpin family E member 1 Enzyme modulator 4.4E-02 0.359 0.885 48
FAS P25445 Fas cell surface death receptor 0.81 0.372 0.923 45
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 44
NOS1 P29475 nitric oxide synthase 1 1.00 0.408 0.885 44
AGER Q15109 advanced glycosylation end-product specific receptor Receptor 6.4E-16 0.420 0.885 43
CAT P04040 catalase Enzyme 1.6E-10 0.359 0.962 41
CCL5 P13501 C-C motif chemokine ligand 5 Signaling 1.8E-03 0.403 0.885 40
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 40
XDH P47989 xanthine dehydrogenase Enzyme 2.6E-22 0.529 0.846 38
CASP9 P55211 caspase 9 Enzyme 7.4E-06 0.458 0.808 37
PPARGC1A Q9UBK2 PPARG coactivator 1 alpha Transcription factor 1.00 0.453 0.885 37
C3 P01024 complement C3 Enzyme modulator 0.90 0.445 0.885 33
CASP8 Q14790 caspase 8 Enzyme 3.7E-06 0.404 0.923 31