Source: GENOMICS_ENGLAND

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
LIG4 P49917 DNA ligase 4 4.2E-06 0.478 0.846 11
CTLA4 P16410 cytotoxic T-lymphocyte associated protein 4 0.94 0.369 0.923 10
ADA2 Q9NZK5 adenosine deaminase 2 Enzyme 8.1E-08 0.545 0.846 8
DOCK8 Q8NF50 dedicator of cytokinesis 8 Enzyme modulator 1.5E-11 0.578 0.731 7
PIK3R1 P27986 phosphoinositide-3-kinase regulatory subunit 1 Kinase 1.00 0.477 0.885 6
IL2RA P01589 interleukin 2 receptor subunit alpha Receptor 5.5E-02 0.389 0.885 5
ORAI1 Q96D31 ORAI calcium release-activated calcium modulator 1 Ion channel 1.9E-05 0.520 0.808 5
RECQL4 O94761 RecQ like helicase 4 Enzyme 3.3E-35 0.496 0.808 5
STIM1 Q13586 stromal interaction molecule 1 0.78 0.501 0.808 5
ZAP70 P43403 zeta chain of T cell receptor associated protein kinase 70 Kinase 0.88 0.497 0.769 5
CARD11 Q9BXL7 caspase recruitment domain family member 11 1.00 0.582 0.615 4
CORO1A P31146 coronin 1A Cellular structure 0.97 0.564 0.692 4
DCLRE1C Q96SD1 DNA cross-link repair 1C 2.5E-07 0.544 0.808 4
IL21R Q9HBE5 interleukin 21 receptor Receptor 1.00 0.550 0.731 4
ITK Q08881 IL2 inducible T cell kinase Kinase 3.1E-08 0.555 0.769 4
STAT1 P42224 signal transducer and activator of transcription 1 Nucleic acid binding 1.00 0.399 0.885 4
UNC119 Q13432 unc-119 lipid binding chaperone Receptor 1.5E-04 0.691 0.462 4
ICOS Q9Y6W8 inducible T cell costimulator 3.1E-02 0.502 0.731 3
MAGT1 Q9H0U3 magnesium transporter 1 Transporter 0.96 0.548 0.769 3
PGM3 O95394 phosphoglucomutase 3 1.5E-05 0.610 0.769 3
PIK3CD O00329 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Kinase 1.00 0.319 0.885 3
RFX5 P48382 regulatory factor X5 Enzyme 2.0E-11 0.650 0.577 3
STK4 Q13043 serine/threonine kinase 4 Kinase 1.5E-02 0.638 0.462 3
TTC7A Q9ULT0 tetratricopeptide repeat domain 7A 1.5E-31 0.641 0.577 3