Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
GCKR Q14397 glucokinase regulator 8.5E-19 0.604 0.615 37 18
ATXN2 Q99700 ataxin 2 Nucleic acid binding 0.85 0.482 0.808 32 28
ABO P16442 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Enzyme 0.427 0.885 26 135
SH2B3 Q9UQQ2 SH2B adaptor protein 3 1.0E-04 0.527 0.692 26 8
FADS2 O95864 fatty acid desaturase 2 1.00 0.575 0.692 25 99
CDKAL1 Q5VV42 CDK5 regulatory subunit associated protein 1 like 1 1.6E-02 0.617 0.615 24 100
HLA-DQA1 P01909 major histocompatibility complex, class II, DQ alpha 1 Immune response 2.4E-02 0.416 0.846 23 65
FADS1 O60427 fatty acid desaturase 1 0.37 0.582 0.769 22 20
TOMM40 O96008 translocase of outer mitochondrial membrane 40 Transporter 0.99 0.590 0.538 22 18
HFE Q30201 homeostatic iron regulator 2.6E-08 0.436 0.846 22 11
HLA-DRA P01903 major histocompatibility complex, class II, DR alpha Immune response 0.52 0.581 0.769 16 53
ALDH1A2 O94788 aldehyde dehydrogenase 1 family member A2 Enzyme 0.36 0.578 0.692 14 220
TMEM258 P61165 transmembrane protein 258 1.9E-03 0.644 0.654 14 28
ZPR1 O75312 ZPR1 zinc finger 8.9E-09 0.674 0.462 14 21
PRKAG2 Q9UGJ0 protein kinase AMP-activated non-catalytic subunit gamma 2 Enzyme modulator 1.00 0.582 0.654 14 16
HBS1L Q9Y450 HBS1 like translational GTPase Enzyme 1.9E-07 0.705 0.462 13 104
MECOM Q03112 MDS1 and EVI1 complex locus 1.00 0.513 0.731 13 10
HNF1A-AS1 HNF1A antisense RNA 1 0.621 0.538 13 10
NAA25 Q14CX7 N-alpha-acetyltransferase 25, NatB auxiliary subunit Enzyme 1.00 0.603 0.692 13 3
UGT1A8 Q9HAW9 UDP glucuronosyltransferase family 1 member A8 1.3E-09 0.588 0.654 12 284
UGT1A10 Q9HAW8 UDP glucuronosyltransferase family 1 member A10 4.6E-19 0.588 0.615 12 264
CETP P11597 cholesteryl ester transfer protein 1.2E-23 0.512 0.731 12 69
IL12A-AS1 IL12A antisense RNA 1 0.633 0.654 12 32
APOB P04114 apolipoprotein B 1.9E-16 0.453 0.808 12 32