Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TP53 P04637 tumor protein p53 transcription factor 0.17 0.251 0.897 63 218
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha kinase; transferase 1.00 0.341 0.897 54 50
FGFR2 P21802 fibroblast growth factor receptor 2 1.00 0.398 0.759 53 57
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase 1.00 0.352 0.793 52 72
HRAS P01112 HRas proto-oncogene, GTPase enzyme modulator 8.7E-02 0.404 0.828 40 20
PTEN P60484 phosphatase and tensin homolog hydrolase; phosphatase 0.82 0.334 0.828 32 230
GNAS O95467 P63092 P84996 Q5JWF2 GNAS complex locus enzyme modulator 0.71 0.443 0.793 29 21
AKT1 P31749 AKT serine/threonine kinase 1 calcium-binding protein; kinase; transfer/carrier protein; transferase 0.98 0.355 0.862 23 4
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 1.8E-03 0.352 0.862 22 26
BRCA2 P51587 BRCA2, DNA repair associated nucleic acid binding 5.5E-24 0.426 0.793 19 2395
MED12 Q93074 mediator complex subunit 12 nucleic acid binding; transcription factor 1.00 0.528 0.655 19 13
IDH1 O75874 isocitrate dehydrogenase (NADP(+)) 1, cytosolic 3.3E-12 0.463 0.690 18 2
FBXW7 Q969H0 F-box and WD repeat domain containing 7 enzyme modulator 1.00 0.511 0.759 17 7
ATM Q13315 ATM serine/threonine kinase kinase; nucleic acid binding; transferase 6.0E-46 0.401 0.862 14 522
PALB2 Q86YC2 partner and localizer of BRCA2 7.3E-20 0.569 0.552 14 242
SMAD4 Q13485 SMAD family member 4 transcription factor 1.00 0.430 0.759 14 105
BRCA1 P38398 BRCA1, DNA repair associated ligase 1.8E-28 0.410 0.862 13 2017
MTOR P42345 mechanistic target of rapamycin kinase kinase; nucleic acid binding; transferase 1.00 0.399 0.793 13 17
CHEK2 O96017 checkpoint kinase 2 1.2E-23 0.494 0.621 12 103
HERC2 O95714 HECT and RLD domain containing E3 ubiquitin protein ligase 2 enzyme modulator; nucleic acid binding 1.00 0.600 0.552 11 8
ERBB3 P21860 erb-b2 receptor tyrosine kinase 3 6.7E-15 0.473 0.690 11 7
C11orf65 Q8NCR3 chromosome 11 open reading frame 65 1.8E-14 0.815 0.345 10 205
POLE Q07864 DNA polymerase epsilon, catalytic subunit 1.8E-25 0.616 0.345 10 6
PPP2R1A P30153 protein phosphatase 2 scaffold subunit Aalpha hydrolase; phosphatase 0.99 0.590 0.517 10 5