Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
PRKAR1A P10644 protein kinase cAMP-dependent type I regulatory subunit alpha 1.00 0.401 0.846 205
TBC1D24 Q9ULP9 TBC1 domain family member 24 Enzyme modulator 1.3E-08 0.530 0.808 153
CDH23 Q9H251 cadherin related 23 3.2E-06 0.539 0.769 137
USP8 P40818 ubiquitin specific peptidase 8 Enzyme 1.00 0.587 0.654 84
CYP11B1 P15538 cytochrome P450 family 11 subfamily B member 1 8.2E-07 0.563 0.615 69
HSD3B2 P26439 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 Enzyme 7.2E-08 0.582 0.500 57
CYP17A1 P05093 cytochrome P450 family 17 subfamily A member 1 2.6E-04 0.462 0.769 51
KCNJ5 P48544 potassium inwardly rectifying channel subfamily J member 5 Ion channel 3.4E-04 0.560 0.577 40
CYP11B2 P19099 cytochrome P450 family 11 subfamily B member 2 7.1E-19 0.553 0.615 37
CACNA1D Q01668 calcium voltage-gated channel subunit alpha1 D Ion channel 1.00 0.582 0.577 36
PDE11A Q9HCR9 phosphodiesterase 11A 8.7E-37 0.612 0.654 34
AIRE O43918 autoimmune regulator 4.0E-12 0.516 0.808 31
PDE8B O95263 phosphodiesterase 8B 1.00 0.638 0.500 31
PRKACA P17612 protein kinase cAMP-activated catalytic subunit alpha Kinase 0.97 0.606 0.692 31
NR3C1 P04150 nuclear receptor subfamily 3 group C member 1 Nuclear receptor 0.97 0.393 0.885 22
CYP21A2 P08686 cytochrome P450 family 21 subfamily A member 2 2.6E-04 0.525 0.769 12