Source: ANIMAL_MODELS

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 138
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 101
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 94
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 92
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 86
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 76
ABCB1 P08183 ATP binding cassette subfamily B member 1 Transporter 1.3E-05 0.344 0.885 75
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 72
HMOX1 P09601 heme oxygenase 1 9.7E-03 0.381 0.923 71
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 64
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 62
CASP3 P42574 caspase 3 Enzyme 0.10 0.351 0.923 62
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 60
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 59
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 58
ICAM1 P05362 intercellular adhesion molecule 1 3.5E-02 0.364 0.962 55
IL6 P05231 interleukin 6 0.32 0.248 0.962 54
FAS P25445 Fas cell surface death receptor 0.81 0.372 0.923 49
EDN1 P05305 endothelin 1 Signaling 0.46 0.380 0.846 48
SERPINE1 P05121 serpin family E member 1 Enzyme modulator 4.4E-02 0.359 0.885 48
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 47
NOS1 P29475 nitric oxide synthase 1 1.00 0.408 0.885 46
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 45
BAX Q07812 BCL2 associated X, apoptosis regulator Signaling 0.32 0.417 0.885 44