Source: ANIMAL_MODELS

Gene Gene Full Name DSI g DPI g pLI Disease Type Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 1636
Gene Symbol: ACE
ACE 		angiotensin I converting enzyme 0.328 0.923 1.0E-37
CUI: C0030193
Disease: Pain
Pain 		phenotype 0.230 None 1.000 1 0 2008 2019
Entrez Id: 6870
Gene Symbol: TACR3
TACR3 		tachykinin receptor 3 0.553 0.769 1.8E-17
CUI: C0030193
Disease: Pain
Pain 		phenotype 0.210 None 0.500 1 0 2007 2009
Entrez Id: 4988
Gene Symbol: OPRM1
OPRM1 		opioid receptor mu 1 0.457 0.808 7.9E-11
CUI: C0030193
Disease: Pain
Pain 		phenotype 0.300 None 0.965 1 0 1999 2020
Entrez Id: 7099
Gene Symbol: TLR4
TLR4 		toll like receptor 4 0.321 0.962 4.6E-09
CUI: C0030193
Disease: Pain
Pain 		phenotype 0.300 None 0.952 1 0 2008 2020
Entrez Id: 5742
Gene Symbol: PTGS1
PTGS1 		prostaglandin-endoperoxide synthase 1 0.460 0.885 6.2E-07
CUI: C0030193
Disease: Pain
Pain 		phenotype 0.250 None 1.000 2 0 2004 2017
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		nitric oxide synthase 3 0.378 0.885 6.7E-07
CUI: C0030193
Disease: Pain
Pain 		phenotype 0.210 None 1.000 1 0 2008 2018
Entrez Id: 7097
Gene Symbol: TLR2
TLR2 		toll like receptor 2 0.361 0.923 1.0E-06
CUI: C0030193
Disease: Pain
Pain 		phenotype 0.200 None 1.000 1 0 2013 2013
Entrez Id: 1312
Gene Symbol: COMT
COMT 		catechol-O-methyltransferase 0.400 0.923 1.1E-06
CUI: C0030193
Disease: Pain
Pain 		phenotype 0.600 None 0.958 1 0 2003 2020
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5 		arachidonate 5-lipoxygenase 0.447 0.885 1.2E-06
CUI: C0030193
Disease: Pain
Pain 		phenotype 0.200 None 1.000 1 0 2009 2009
Entrez Id: 199
Gene Symbol: AIF1
AIF1 		allograft inflammatory factor 1 0.521 0.808 1.9E-06
CUI: C0030193
Disease: Pain
Pain 		phenotype 0.220 None 1.000 1 0 2008 2019
Entrez Id: 887
Gene Symbol: CCKBR
CCKBR 		cholecystokinin B receptor 0.573 0.615 2.1E-06
CUI: C0030193
Disease: Pain
Pain 		phenotype 0.200 None 1.000 1 0 2006 2006
Entrez Id: 1269
Gene Symbol: CNR2
CNR2 		cannabinoid receptor 2 0.509 0.846 6.5E-06
CUI: C0030193
Disease: Pain
Pain 		phenotype 0.300 None 1.000 1 0 2007 2019
Entrez Id: 55607
Gene Symbol: PPP1R9A
PPP1R9A 		protein phosphatase 1 regulatory subunit 9A 0.769 0.269 1.1E-05
CUI: C0030193
Disease: Pain
Pain 		phenotype 0.200 None 1.000 1 0 2010 2010
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		ATP binding cassette subfamily B member 1 0.344 0.885 1.3E-05
CUI: C0030193
Disease: Pain
Pain 		phenotype 0.300 None 0.950 1 0 2008 2019
Entrez Id: 885
Gene Symbol: CCK
CCK 		cholecystokinin 0.453 0.846 3.3E-05
CUI: C0030193
Disease: Pain
Pain 		phenotype 0.260 None 1.000 1 0 2007 2019
Entrez Id: 834
Gene Symbol: CASP1
CASP1 		caspase 1 0.413 0.885 3.5E-05
CUI: C0030193
Disease: Pain
Pain 		phenotype 0.230 None 1.000 1 0 2009 2019
Entrez Id: 6869
Gene Symbol: TACR1
TACR1 		tachykinin receptor 1 0.502 0.885 3.8E-04
CUI: C0030193
Disease: Pain
Pain 		phenotype 0.280 None 1.000 1 0 2001 2019
Entrez Id: 6352
Gene Symbol: CCL5
CCL5 		C-C motif chemokine ligand 5 0.403 0.885 1.8E-03
CUI: C0030193
Disease: Pain
Pain 		phenotype 0.220 None 1.000 1 0 2001 2017
Entrez Id: 4985
Gene Symbol: OPRD1
OPRD1 		opioid receptor delta 1 0.604 0.731 3.3E-03
CUI: C0030193
Disease: Pain
Pain 		phenotype 0.290 None 1.000 1 0 2003 2020
Entrez Id: 623
Gene Symbol: BDKRB1
BDKRB1 		bradykinin receptor B1 0.619 0.731 4.7E-03
CUI: C0030193
Disease: Pain
Pain 		phenotype 0.500 None 1.000 1 0 2007 2010
Entrez Id: 6367
Gene Symbol: CCL22
CCL22 		C-C motif chemokine ligand 22 0.500 0.846 8.4E-03
CUI: C0030193
Disease: Pain
Pain 		phenotype 0.220 None 1.000 1 0 2001 2019
Entrez Id: 729230
Gene Symbol: CCR2
CCR2 		C-C motif chemokine receptor 2 0.418 0.846 2.3E-02
CUI: C0030193
Disease: Pain
Pain 		phenotype 0.270 None 1.000 1 0 2008 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG 		peroxisome proliferator activated receptor gamma 0.358 0.885 2.9E-02
CUI: C0030193
Disease: Pain
Pain 		phenotype 0.200 None 1.000 1 0 2008 2008
Entrez Id: 3606
Gene Symbol: IL18
IL18 		interleukin 18 0.365 0.923 3.1E-02
CUI: C0030193
Disease: Pain
Pain 		phenotype 0.260 None 1.000 1 0 2009 2019
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1 		intercellular adhesion molecule 1 0.364 0.962 3.5E-02
CUI: C0030193
Disease: Pain
Pain 		phenotype 0.230 None 1.000 1 0 2010 2018