Gene Gene Full Name DSI g DPI g pLI Disease Type Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 8803
Gene Symbol: SUCLA2
SUCLA2
succinate-CoA ligase ADP-forming subunit beta 0.566 0.654 2.3E-03
Leigh Syndrome Due To Mitochondrial Complex II Deficiency
disease 0.300 definitive 1.000 13 0 2005 2017
Entrez Id: 4719
Gene Symbol: NDUFS1
NDUFS1
NADH:ubiquinone oxidoreductase core subunit S1 0.595 0.692 6.6E-11
Leigh Syndrome Due To Mitochondrial Complex II Deficiency
disease 0.300 definitive 1.000 12 0 1991 2016
Entrez Id: 4724
Gene Symbol: NDUFS4
NDUFS4
NADH:ubiquinone oxidoreductase subunit S4 0.587 0.808 3.1E-04
Leigh Syndrome Due To Mitochondrial Complex II Deficiency
disease 0.300 definitive 1.000 12 0 2003 2018
Entrez Id: 4722
Gene Symbol: NDUFS3
NDUFS3
NADH:ubiquinone oxidoreductase core subunit S3 0.581 0.769 5.8E-04
Leigh Syndrome Due To Mitochondrial Complex II Deficiency
disease 0.300 moderate 1.000 10 0 1998 2018
Entrez Id: 4694
Gene Symbol: NDUFA1
NDUFA1
NADH:ubiquinone oxidoreductase subunit A1 0.636 0.423 0.55
Leigh Syndrome Due To Mitochondrial Complex II Deficiency
disease 0.300 moderate 1.000 10 0 1996 2018
Entrez Id: 4723
Gene Symbol: NDUFV1
NDUFV1
NADH:ubiquinone oxidoreductase core subunit V1 0.617 0.538 6.4E-11
Leigh Syndrome Due To Mitochondrial Complex II Deficiency
disease 0.300 definitive 1.000 10 0 2001 2019
Entrez Id: 23474
Gene Symbol: ETHE1
ETHE1
ETHE1 persulfide dioxygenase 0.686 0.346 4.6E-06
Leigh Syndrome Due To Mitochondrial Complex II Deficiency
disease 0.300 definitive 1.000 10 0 2006 2017
Entrez Id: 80704
Gene Symbol: SLC19A3
SLC19A3
solute carrier family 19 member 3 0.610 0.692 0.10
Leigh Syndrome Due To Mitochondrial Complex II Deficiency
disease 0.300 definitive 1.000 10 0 2010 2016
Entrez Id: 8802
Gene Symbol: SUCLG1
SUCLG1
succinate-CoA ligase GDP/ADP-forming subunit alpha 0.666 0.423 4.8E-04
Leigh Syndrome Due To Mitochondrial Complex II Deficiency
disease 0.300 moderate 1.000 9 0 1997 2018
Entrez Id: 6834
Gene Symbol: SURF1
SURF1
SURF1 cytochrome c oxidase assembly factor 0.578 0.654 1.6E-13
Leigh Syndrome Due To Mitochondrial Complex II Deficiency
disease 0.300 definitive 1.000 9 0 1998 2018
Entrez Id: 4695
Gene Symbol: NDUFA2
NDUFA2
NADH:ubiquinone oxidoreductase subunit A2 0.617 0.577 0.77
Leigh Syndrome Due To Mitochondrial Complex II Deficiency
disease 0.300 moderate 1.000 9 0 1998 2018
Entrez Id: 4728
Gene Symbol: NDUFS8
NDUFS8
NADH:ubiquinone oxidoreductase core subunit S8 0.636 0.538 0.17
Leigh Syndrome Due To Mitochondrial Complex II Deficiency
disease 0.300 moderate 1.000 9 0 1998 2018
Entrez Id: 5160
Gene Symbol: PDHA1
PDHA1
pyruvate dehydrogenase E1 subunit alpha 1 0.581 0.538 0.99
Leigh Syndrome Due To Mitochondrial Complex II Deficiency
disease 0.300 definitive 1.000 8 0 1993 2017
Entrez Id: 6389
Gene Symbol: SDHA
SDHA
succinate dehydrogenase complex flavoprotein subunit A 0.517 0.731 2.6E-10
Leigh Syndrome Due To Mitochondrial Complex II Deficiency
disease 0.300 moderate 1.000 8 0 1992 2015
Entrez Id: 10128
Gene Symbol: LRPPRC
LRPPRC
leucine rich pentatricopeptide repeat containing 0.493 0.769 2.3E-10
Leigh Syndrome Due To Mitochondrial Complex II Deficiency
disease 0.300 definitive 1.000 8 0 2003 2017
Entrez Id: 54902
Gene Symbol: TTC19
TTC19
tetratricopeptide repeat domain 19 0.663 0.385 1.4E-08
Leigh Syndrome Due To Mitochondrial Complex II Deficiency
disease 0.300 definitive 1.000 8 0 2011 2018
Entrez Id: 9997
Gene Symbol: SCO2
SCO2
synthesis of cytochrome C oxidase 2 0.479 0.846 7.5E-07
Leigh Syndrome Due To Mitochondrial Complex II Deficiency
disease 0.300 definitive 1.000 7 0 1999 2010
Entrez Id: 10667
Gene Symbol: FARS2
FARS2
phenylalanyl-tRNA synthetase 2, mitochondrial 0.615 0.731 9.3E-09
Leigh Syndrome Due To Mitochondrial Complex II Deficiency
disease 0.300 moderate 1.000 7 0 2012 2017
Entrez Id: 1352
Gene Symbol: COX10
COX10
cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 0.623 0.654 8.4E-02
Leigh Syndrome Due To Mitochondrial Complex II Deficiency
disease 0.300 moderate 1.000 7 0 1990 2015
Entrez Id: 374291
Gene Symbol: NDUFS7
NDUFS7
NADH:ubiquinone oxidoreductase core subunit S7 0.579 0.769 0.91
Leigh Syndrome Due To Mitochondrial Complex II Deficiency
disease 0.300 moderate 1.000 7 0 1999 2019
Entrez Id: 1355
Gene Symbol: COX15
COX15
cytochrome c oxidase assembly homolog COX15 0.638 0.538 1.1E-13
Leigh Syndrome Due To Mitochondrial Complex II Deficiency
disease 0.300 limited 1.000 6 0 2002 2015
Entrez Id: 55572
Gene Symbol: FOXRED1
FOXRED1
FAD dependent oxidoreductase domain containing 1 0.633 0.462 2.0E-16
Leigh Syndrome Due To Mitochondrial Complex II Deficiency
disease 0.300 moderate 1.000 6 0 2010 2019
Entrez Id: 85476
Gene Symbol: GFM1
GFM1
G elongation factor mitochondrial 1 0.623 0.692 9.3E-13
Leigh Syndrome Due To Mitochondrial Complex II Deficiency
disease 0.300 moderate 1.000 6 0 2007 2017
Entrez Id: 617
Gene Symbol: BCS1L
BCS1L
BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone 0.534 0.808 4.7E-13
Leigh Syndrome Due To Mitochondrial Complex II Deficiency
disease 0.300 limited 1.000 6 0 1999 2017
Entrez Id: 4704
Gene Symbol: NDUFA9
NDUFA9
NADH:ubiquinone oxidoreductase subunit A9 0.653 0.385 4.8E-03
Leigh Syndrome Due To Mitochondrial Complex II Deficiency
disease 0.300 moderate 1.000 5 0 2012 2018