×
Entrez Id: 472
Gene Symbol: ATM
ATM
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
The depletion of ATM inhibits colon cancer proliferation and migration via B56γ2-mediated Chk1/p53/CD44 cascades.
28093285 2017
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Downregulated Ku70 and ATM associated to poor prognosis in colorectal cancer among Chinese patients.
25368522 2014
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Cancer Susceptibility Gene Mutations in Individuals With Colorectal Cancer.
28135145 2017
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer.
27978560 2017
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Germline mutations in oncogene-induced senescence pathways are associated with multiple sessile serrated adenomas.
24512911 2014
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN.
23154512 2012
×
Entrez Id: 580
Gene Symbol: BARD1
BARD1
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Expression of oncogenic BARD1 isoforms affects colon cancer progression and correlates with clinical outcome.
22814582 2012
×
Entrez Id: 580
Gene Symbol: BARD1
BARD1
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Expression of an Oncogenic BARD1 Splice Variant Impairs Homologous Recombination and Predicts Response to PARP-1 Inhibitor Therapy in Colon Cancer.
27197561 2016
×
Entrez Id: 580
Gene Symbol: BARD1
BARD1
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Adenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1.
11498787 2001
×
Entrez Id: 580
Gene Symbol: BARD1
BARD1
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Whole-exome sequencing identifies rare pathogenic variants in new predisposition genes for familial colorectal cancer.
25058500 2015
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
E-cadherin germline mutations in familial gastric cancer.
9537325 1998
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells.
10051639 1999
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer.
10072428 1999
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Screening E-cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindred.
11968083 2002
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Loss of CDH1 (E-cadherin) expression is associated with infiltrative tumour growth and lymph node metastasis.
26742007 2016
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Identification of seven novel germline mutations in the human E-cadherin (CDH1) gene.
17221870 2007
×
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
p27kip1 deficiency impairs G2/M arrest in response to DNA damage, leading to an increase in genetic instability.
17954563 2008
×
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Down-regulation of p27 is associated with development of colorectal adenocarcinoma metastases.
9736017 1998
×
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Tumorigenesis in p27/p53- and p18/p53-double null mice: functional collaboration between the pRb and p53 pathways.
15584024 2005
×
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Comparative effects of overexpression of p27Kip1 and p21Cip1/Waf1 on growth and differentiation in human colon carcinoma cells.
9926925 1999
×
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
The murine gene p27Kip1 is haplo-insufficient for tumour suppression.
9823898 1998
×
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice.
12086850 2002
×
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Whole-exome sequencing identifies rare pathogenic variants in new predisposition genes for familial colorectal cancer.
25058500 2015
×
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
p27kip1 Regulates cdk2 activity in the proliferating zone of the mouse intestinal epithelium: potential role in neoplasia.
17631145 2007
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response.
16478982 2006