Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma 		0.600 Biomarker RGD Tissue inhibitor-1 of metalloproteinases is a specific inhibitor of MMP-9; the MMP-9 and TIMP-1 imbalance could lead to airway inflammation and remodeling in lung disease such as asthma. 16191269

2005
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Biomarker RGD Upregulation of tissue inhibitor of metalloproteases-1 (TIMP-1) and procollagen-N-peptidase in hypertension-induced renal damage. 17977875

2008
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.600 Biomarker RGD Regulation of collagen degradation in the rat myocardium after infarction. 8531210

1995
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.600 Biomarker RGD Bone marrow mesenchymal stem cell transplantation combined with perindopril treatment attenuates infarction remodelling in a rat model of acute myocardial infarction. 16845718

2006
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.600 Biomarker RGD Expression of MMP2, MMP9 and MMP3 in breast cancer brain metastasis in a rat model. 16158251

2005
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.600 Biomarker RGD These data document the requirement for MMP-9 expression in metastasis in this system. 8912869

1996
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.600 Biomarker RGD The sources and effects of MMP-2 and MMP-9 differ in BLM-induced rat pulmonary fibrosis. 17121240

2006
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia 		0.560 Biomarker RGD Delayed minocycline inhibits ischemia-activated matrix metalloproteinases 2 and 9 after experimental stroke. 16846501

2006
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.540 Biomarker RGD Diclofenac, a selective COX-2 inhibitor, inhibits DMH-induced colon tumorigenesis through suppression of MCP-1, MIP-1α and VEGF. 21268133

2011
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.510 Biomarker RGD Temporal exposure of cryptic collagen epitopes within ischemic muscle during hindlimb reperfusion. 16251419

2005
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.510 Biomarker RGD Matrix metalloprotease expressions in both reperfusion lung injury and oleic acid lung injury models and the protective effects of ilomastat. 19545667

2009
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0162872
Disease: Aortic Aneurysm, Thoracic
Aortic Aneurysm, Thoracic 		0.510 Biomarker RGD Elevation of ADAM10, ADAM17, MMP-2 and MMP-9 expression with media degeneration features CaCl2-induced thoracic aortic aneurysm in a rat model. 20621845

2010
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 Biomarker RGD Regulation of matrix metalloproteinase-9 by epigenetic modifications and the development of diabetic retinopathy. 23423566

2013
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 Biomarker RGD [Modulative effect of zhenqing recipe on expressions of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in experimental type 2 diabetic rats]. 17569353

2006
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0024668
Disease: Mammary Neoplasms, Experimental
Mammary Neoplasms, Experimental 		0.500 Biomarker RGD Evaluation of molecular markers in a rat model of mammary carcinogenesis. 19725228

2009
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0026766
Disease: Multiple Organ Failure
Multiple Organ Failure 		0.500 Biomarker RGD Here, we developed a rat model for MODS caused by trauma and infection and analyzed the dynamic level of MMP-9 and determined the relationship between MMP-9 level and early phase of organ injury in MODS rat. 21964536

2012
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0038358
Disease: Gastric ulcer
Gastric ulcer 		0.500 Biomarker RGD We investigated the activity and expression of MMP-9 and -2 in ethanol-induced acute gastric ulceration in rats. 17603938

2007
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C1527311
Disease: Brain Edema
Brain Edema 		0.500 Biomarker RGD Time course of upregulation of inflammatory mediators in the hemorrhagic brain in rats: correlation with brain edema. 20541575

2010
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.300 Biomarker RGD Our results suggest that the expression of CD40 and CD40L in the blood cells and the activities of MMP-2 and MMP-9 in plasma were higher in As group than those in Normal group, indicating that they may contribute to the formation of atherosclerosis. 16317521

2006
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0014175
Disease: Endometriosis
Endometriosis 		0.300 Biomarker RGD Higher expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (Flk-1) and metalloproteinase-9 (MMP-9) in a rat model of peritoneal endometriosis is similar to cancer diseases. 20085636

2010
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 Biomarker RGD Matrix metalloproteinase inhibition attenuates left ventricular remodeling and dysfunction in a rat model of progressive heart failure. 11342481

2001
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 Biomarker RGD Activation of signaling molecules and matrix metalloproteinases in right ventricular myocardium of rats with pulmonary hypertension. 17913382

2007
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.300 Biomarker RGD Matrix metalloproteinase inhibition attenuates left ventricular remodeling and dysfunction in a rat model of progressive heart failure. 11342481

2001
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.300 Biomarker RGD Activation of signaling molecules and matrix metalloproteinases in right ventricular myocardium of rats with pulmonary hypertension. 17913382

2007
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases 		0.300 Biomarker RGD Rosuvastatin treatment prevents progressive kidney inflammation and fibrosis in stroke-prone rats. 17392157

2007