Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 Therapeutic RGD Although compelling evidence of a beneficial effect exists for the use of angiotensin-converting enzyme inhibitors (ACEIs) and low-protein diets, there is little evidence on whether carbon adsorbent has an effect on retardation of the progression of CRF. 14586729

2003

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 Biomarker RGD Only animals from the 1WIK group developed severe chronic renal failure, glomerulosclerosis, interstitial fibrosis, and upregulation of transforming growth factor-beta(1) (TGF-beta(1)) gene, which was associated with increased TGF-beta(1) protein expression in tubular epithelial cells, arterioles, and in areas of mononuclear interstitial cell infiltrate. 10919844

2000

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 Biomarker RGD Changes of adiponectin and its receptors in rats following chronic renal failure. 24028144

2014

Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 Biomarker RGD Our findings indicate localized expression of MCP-1 in proximal tubular cells in the remnant kidney and suggest that MCP-1 in proximal tubular cells is involved in tubulointerstitial damage in chronic kidney failure associated with glomerular hypertension. 12080327

2002

Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 Therapeutic RGD Sedentary CRF rats exhibited azotemia, hypertension, anemia, oxidative stress, activation of NF-kappaB and upregulations of reactive oxygen species-generating enzyme, NAD(P)H oxidase, MCP-1, cyclooxygenase-2 (COX-2), and PAI-1 in LV. 18797164

2009

Entrez Id: 57817
Gene Symbol: HAMP
HAMP
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.570 Biomarker RGD Erythropoietin regulates intestinal iron absorption in a rat model of chronic renal failure. 20631677

2010

Entrez Id: 1535
Gene Symbol: CYBA
CYBA
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.550 Biomarker RGD Niacin ameliorates oxidative stress, inflammation, proteinuria, and hypertension in rats with chronic renal failure. 19420110

2009

Entrez Id: 51094
Gene Symbol: ADIPOR1
ADIPOR1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.530 Biomarker RGD Changes of adiponectin and its receptors in rats following chronic renal failure. 24028144

2014

Entrez Id: 5970
Gene Symbol: RELA
RELA
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.510 Biomarker RGD Melatonin ameliorates oxidative stress, inflammation, proteinuria, and progression of renal damage in rats with renal mass reduction. 18077597

2008

Entrez Id: 1536
Gene Symbol: CYBB
CYBB
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.510 Biomarker RGD Renal tissue abundance of gp91(phox) subunit of NAD(P)H oxidase was elevated in the untreated CRF group and was partially reduced in the iron dextran-treated CRF group. 15550752

2005

Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.510 Therapeutic RGD An integrated lipidomics and metabolomics reveal nephroprotective effect and biochemical mechanism of Rheum officinale in chronic renal failure. 26903149

2016

Entrez Id: 38
Gene Symbol: ACAT1
ACAT1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.500 Biomarker RGD Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. 19878707

2010

Entrez Id: 847
Gene Symbol: CAT
CAT
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.500 Biomarker RGD Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure. 20007347

2010

Entrez Id: 873
Gene Symbol: CBR1
CBR1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.500 Biomarker RGD Effect of experimental kidney disease on the functional expression of hepatic reductases. 25332430

2015

Entrez Id: 6721
Gene Symbol: SREBF2
SREBF2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.500 Biomarker RGD Despite increased SREBP-2 gene expression we found LDL-receptor mRNA level to be lower than in controls, suggesting SREBP-2 independent mechanisms of LDL-receptor transcriptional regulation in CRF rats. 16814791

2007

Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.500 Biomarker RGD Inhibition of mineralocorticoid receptor is a renoprotective effect of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pitavastatin. 21119529

2011

Entrez Id: 4036
Gene Symbol: LRP2
LRP2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.310 Biomarker RGD Modulation of gene expression by moxonidine in rats with chronic renal failure. 15266031

2004

Entrez Id: 5741
Gene Symbol: PTH
PTH
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.300 Biomarker RGD Two novel vitamin D receptor modulators with similar structures exhibit different hypercalcemic effects in 5/6 nephrectomized uremic rats. 23548814

2013

Entrez Id: 5741
Gene Symbol: PTH
PTH
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.300 Biomarker RGD The pathophysiology of early-stage chronic kidney disease-mineral bone disorder (CKD-MBD) and response to phosphate binders in the rat. 21826734

2011

Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.300 Biomarker RGD Angiotensin type 2 receptor antagonism confers renal protection in a rat model of progressive renal injury. 12089373

2002

Entrez Id: 5741
Gene Symbol: PTH
PTH
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.300 Biomarker RGD Dietary phosphate binding and loading alter kidney angiotensin-converting enzyme mRNA and protein content in 5/6 nephrectomized rats. 22517117

2012

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.300 Therapeutic RGD Increased circulating trimethylamine N-oxide contributes to endothelial dysfunction in a rat model of chronic kidney disease. 29247650

2018

Entrez Id: 6582
Gene Symbol: SLC22A2
SLC22A2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.300 Biomarker RGD Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy. 12110012

2002

Entrez Id: 8074
Gene Symbol: FGF23
FGF23
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.300 Biomarker RGD Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease. 20016468

2010

Entrez Id: 6582
Gene Symbol: SLC22A2
SLC22A2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.300 Biomarker RGD Protein and mRNA expression levels of Oat1, Oat 3, Oct1, and Oct2 were significantly decreased in adenine-induced CRF rats. 23280877

2013