Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0524851
Disease: Neurodegenerative Disorders
Neurodegenerative Disorders 		0.400 Therapeutic CTD_human Thus, SIRT1 constitutes a unique molecular link between aging and human neurodegenerative disorders and provides a promising avenue for therapeutic intervention. 17581637

2007
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0524851
Disease: Neurodegenerative Disorders
Neurodegenerative Disorders 		0.400 Therapeutic CTD_human SIRT1 activation confers neuroprotection in experimental optic neuritis. 17652729

2007
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0027746
Disease: Nerve Degeneration
Nerve Degeneration 		0.300 Therapeutic CTD_human Furthermore, injection of SIRT1 lentivirus in the hippocampus of p25 transgenic mice conferred significant protection against neurodegeneration. 17581637

2007
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0270715
Disease: Degenerative Diseases, Central Nervous System
Degenerative Diseases, Central Nervous System 		0.300 Therapeutic CTD_human SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. 17581637

2007
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0270715
Disease: Degenerative Diseases, Central Nervous System
Degenerative Diseases, Central Nervous System 		0.300 Therapeutic CTD_human SIRT1 activation confers neuroprotection in experimental optic neuritis. 17652729

2007
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0751733
Disease: Degenerative Diseases, Spinal Cord
Degenerative Diseases, Spinal Cord 		0.300 Therapeutic CTD_human SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. 17581637

2007
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0751733
Disease: Degenerative Diseases, Spinal Cord
Degenerative Diseases, Spinal Cord 		0.300 Therapeutic CTD_human SIRT1 activation confers neuroprotection in experimental optic neuritis. 17652729

2007
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0019693
Disease: HIV Infections
HIV Infections 		0.320 Biomarker CTD_human SIRT1 regulates Tat-induced HIV-1 transactivation through activating AMP-activated protein kinase. 19720090

2009
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C4505456
Disease: HIV Coinfection
HIV Coinfection 		0.300 Biomarker CTD_human SIRT1 regulates Tat-induced HIV-1 transactivation through activating AMP-activated protein kinase. 19720090

2009
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.600 Biomarker CTD_human Insulin resistance and subclinical atherosclerosis are associated with SIRT1 downregulation in monocytes. 20068143

2010
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker CTD_human In vivo, insulin resistance and metabolic syndrome were associated with low PBMC SIRT1 gene and protein expression. 20068143

2010
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0021655
Disease: Insulin Resistance
Insulin Resistance 		0.500 Therapeutic CTD_human In vivo, insulin resistance and metabolic syndrome were associated with low PBMC SIRT1 gene and protein expression. 20068143

2010
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0021655
Disease: Insulin Resistance
Insulin Resistance 		0.500 Biomarker CTD_human In vivo, insulin resistance and metabolic syndrome were associated with low PBMC SIRT1 gene and protein expression. 20068143

2010
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.400 Biomarker CTD_human E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells. 19839049

2010
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 Biomarker CTD_human E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells. 19839049

2010
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0009319
Disease: Colitis
Colitis 		0.340 Biomarker CTD_human Colitis was associated with a decrease in silent mating type information regulation-1 (SIRT1) gene expression and an increase in p-inhibitory kappaB expression and nuclear transcription factor-kappaB (NF-kappaB) activation. 19940103

2010
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.340 Biomarker CTD_human E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells. 19839049

2010
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0016059
Disease: Fibrosis
Fibrosis 		0.300 Biomarker CTD_human Resveratrol inhibits renal fibrosis in the obstructed kidney: potential role in deacetylation of Smad3. 20651248

2010
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury 		0.300 Therapeutic CTD_human Silent information regulator 1 protects the heart from ischemia/reperfusion. 21060073

2010
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0920563
Disease: Insulin Sensitivity
Insulin Sensitivity 		0.300 Therapeutic CTD_human Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms. 20068143

2010
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0920563
Disease: Insulin Sensitivity
Insulin Sensitivity 		0.300 Biomarker CTD_human Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms. 20068143

2010
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human 		0.300 Biomarker CTD_human E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells. 19839049

2010
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C1563937
Disease: Atherogenesis
Atherogenesis 		0.300 Biomarker CTD_human Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms. 20068143

2010
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C1623038
Disease: Cirrhosis
Cirrhosis 		0.300 Biomarker CTD_human Resveratrol inhibits renal fibrosis in the obstructed kidney: potential role in deacetylation of Smad3. 20651248

2010
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C4704874
Disease: Mammary Carcinoma, Human
Mammary Carcinoma, Human 		0.300 Biomarker CTD_human E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells. 19839049

2010