Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0020649
Disease: Hypotension
Hypotension 		0.500 Biomarker CTD_human Mutant mice did not respond to cannabinoid drugs, demonstrating the exclusive role of the CB1 receptor in mediating analgesia, reinforcement, hypothermia, hypolocomotion, and hypotension. 9888857

1999
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C1510472
Disease: Drug Dependence
Drug Dependence 		0.380 Biomarker CTD_human Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. 9888857

1999
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0038580
Disease: Substance Dependence
Substance Dependence 		0.350 Biomarker CTD_human Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. 9888857

1999
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0038586
Disease: Substance Use Disorders
Substance Use Disorders 		0.340 Biomarker CTD_human Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. 9888857

1999
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0740858
Disease: Substance abuse problem
Substance abuse problem 		0.340 Biomarker CTD_human Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. 9888857

1999
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0013146
Disease: Drug abuse
Drug abuse 		0.320 Biomarker CTD_human Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. 9888857

1999
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0007370
Disease: Catalepsy
Catalepsy 		0.300 Biomarker CTD_human Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. 10318961

1999
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0013170
Disease: Drug habituation
Drug habituation 		0.300 Biomarker CTD_human Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. 9888857

1999
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0013222
Disease: Drug Use Disorders
Drug Use Disorders 		0.300 Biomarker CTD_human Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. 9888857

1999
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0020672
Disease: Hypothermia, natural
Hypothermia, natural 		0.300 Biomarker CTD_human Mutant mice did not respond to cannabinoid drugs, demonstrating the exclusive role of the CB1 receptor in mediating analgesia, reinforcement, hypothermia, hypolocomotion, and hypotension. 9888857

1999
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0029231
Disease: Organic Mental Disorders, Substance-Induced
Organic Mental Disorders, Substance-Induced 		0.300 Biomarker CTD_human Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. 9888857

1999
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0233612
Disease: Waxy flexibility
Waxy flexibility 		0.300 Biomarker CTD_human Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. 10318961

1999
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0236969
Disease: Substance-Related Disorders
Substance-Related Disorders 		0.300 Biomarker CTD_human Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. 9888857

1999
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C4316881
Disease: Prescription Drug Abuse
Prescription Drug Abuse 		0.300 Biomarker CTD_human Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. 9888857

1999
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0026650
Disease: Movement Disorders
Movement Disorders 		0.300 Therapeutic CTD_human Cerebellar CB(1) receptor mediation of Delta(9)-THC-induced motor incoordination and its potentiation by ethanol and modulation by the cerebellar adenosinergic A(1) receptor in the mouse. 10802025

2000
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0266487
Disease: Etat Marbre
Etat Marbre 		0.300 Therapeutic CTD_human Cerebellar CB(1) receptor mediation of Delta(9)-THC-induced motor incoordination and its potentiation by ethanol and modulation by the cerebellar adenosinergic A(1) receptor in the mouse. 10802025

2000
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0027746
Disease: Nerve Degeneration
Nerve Degeneration 		0.500 Biomarker CTD_human Neuroprotection by Delta9-tetrahydrocannabinol, the main active compound in marijuana, against ouabain-induced in vivo excitotoxicity. 11517236

2001
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0027746
Disease: Nerve Degeneration
Nerve Degeneration 		0.500 Therapeutic CTD_human Neuroprotection by Delta9-tetrahydrocannabinol, the main active compound in marijuana, against ouabain-induced in vivo excitotoxicity. 11517236

2001
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.320 Biomarker CTD_human Endocannabinoids acting at vascular CB1 receptors mediate the vasodilated state in advanced liver cirrhosis. 11433348

2001
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis 		0.310 Biomarker CTD_human These results implicate anandamide and vascular CB1 receptors in the vasodilated state in advanced cirrhosis and indicate a novel approach for its management. 11433348

2001
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.370 Therapeutic CTD_human Cannabinoids inhibit neurodegeneration in models of multiple sclerosis. 12876144

2003
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0036572
Disease: Seizures
Seizures 		0.370 Biomarker CTD_human By demonstrating a role for the endogenous cannabinoid system in regulating seizure activity, these studies define a role for the endogenous cannabinoid system in modulating neuroexcitation and suggest that plasticity of the CB1 receptor occurs with epilepsy. 12954810

2003
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C4048158
Disease: Convulsions
Convulsions 		0.310 Biomarker CTD_human The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsy. 12954810

2003
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C4317109
Disease: Epileptic Seizures
Epileptic Seizures 		0.310 Biomarker CTD_human The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsy. 12954810

2003
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0022333
Disease: Jacksonian Seizure
Jacksonian Seizure 		0.300 Biomarker CTD_human The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsy. 12954810

2003