Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
1.000 Biomarker MGD This suggestion may also provide a rational explanation for a previous unexpected finding that cigarette smoking appears to reduce the breast cancer risk of BRCA2 mutation carriers. 14981540

2004

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
1.000 Biomarker MGD Recent studies have suggested a role for the APC I1307K allele as a low-penetrance breast cancer susceptibility gene that enhances the phenotypic effects of BRCA1 and BRCA2 mutations. 11215675

2001

Entrez Id: 580
Gene Symbol: BARD1
BARD1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
1.000 Biomarker MGD

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
1.000 Biomarker MGD

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
1.000 Biomarker MGD

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
1.000 Biomarker MGD

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
1.000 Biomarker MGD

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.800 Biomarker MGD

Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.800 Biomarker MGD To dissect the role of Cav-1 loss-of-function in the pathogenesis of human breast cancers, we used Cav-1(-/-) null mice as a model system. 19342371

2009

Entrez Id: 6772
Gene Symbol: STAT1
STAT1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker MGD Stimulation by TLR5 modulates osteoclast differentiation through STAT1/IFN-beta. 18209032

2008

Entrez Id: 6772
Gene Symbol: STAT1
STAT1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker MGD Interestingly, the expression levels of STAT1 in the tumor-infiltrating stromal cells remain elevated, indicating that single-cell resolution analysis of STAT1 level in primary breast cancer biopsies is necessary for accurate assessment. 22264274

2012

Entrez Id: 6772
Gene Symbol: STAT1
STAT1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker MGD The role of STAT1/IRF-1 on synergistic ROS production and loss of mitochondrial transmembrane potential during hepatic cell death induced by LPS/d-GalN. 17475277

2007

Entrez Id: 6772
Gene Symbol: STAT1
STAT1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker MGD The carboxyl-terminal activation domain of the STAT-1 transcription factor enhances ischemia/reperfusion-induced apoptosis in cardiac myocytes. 12223448

2002

Entrez Id: 6772
Gene Symbol: STAT1
STAT1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker MGD EGCG mitigates neurotoxicity mediated by HIV-1 proteins gp120 and Tat in the presence of IFN-gamma: role of JAK/STAT1 signaling and implications for HIV-associated dementia. 17078933

2006

Entrez Id: 6772
Gene Symbol: STAT1
STAT1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker MGD Bacillus anthracis spores and lethal toxin induce IL-1beta via functionally distinct signaling pathways. 18493980

2008

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 Biomarker MGD A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis. 19578404

2009

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 Biomarker MGD Cancer stemness in Wnt-driven mammary tumorigenesis. 23955540

2014

Entrez Id: 7471
Gene Symbol: WNT1
WNT1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.300 Biomarker MGD

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.300 Biomarker MGD We conclude from these studies that MET may play a critical role in the development of the most aggressive breast cancers and may be a rational therapeutic target. 19567831

2009

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.300 Biomarker MGD

Entrez Id: 3082
Gene Symbol: HGF
HGF
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.300 Biomarker MGD

Entrez Id: 6597
Gene Symbol: SMARCA4
SMARCA4
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.300 Biomarker MGD We also demonstrate that Brg1+/- mammary tumors have relatively heterogeneous gene expression profiles with similarities and differences compared to other mouse models of breast cancer. 17637742

2008

Entrez Id: 2120
Gene Symbol: ETV6
ETV6
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.240 Biomarker MGD

Entrez Id: 9700
Gene Symbol: ESPL1
ESPL1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.220 Biomarker MGD