Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.700 Biomarker MGD

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.370 Biomarker MGD

Entrez Id: 8567
Gene Symbol: MADD
MADD
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.230 Biomarker MGD

Entrez Id: 4779
Gene Symbol: NFE2L1
NFE2L1
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.210 Biomarker MGD

Entrez Id: 2305
Gene Symbol: FOXM1
FOXM1
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.210 Biomarker MGD

Entrez Id: 5584
Gene Symbol: PRKCI
PRKCI
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.200 Biomarker MGD

Entrez Id: 90480
Gene Symbol: GADD45GIP1
GADD45GIP1
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.200 Biomarker MGD

Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD "Endocrine pancreatic cells of postnatal ""diabetes"" (db) mice in cell culture." 393618

1979
Entrez Id: 2645
Gene Symbol: GCK
GCK
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.900 Therapeutic RGD Glucokinase activators (GKAs) are currently being developed as new therapies for type 2 diabetes and have been shown to enhance beta cell survival and proliferation in vitro. 22234649

2012
Entrez Id: 434
Gene Symbol: ASIP
ASIP
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.200 Biomarker CTD_mouse A molecular model for the genetic and phenotypic characteristics of the mouse lethal yellow (Ay) mutation. 8146154

1994
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.300 Therapeutic RGD A novel natural Nrf2 activator with PPARγ-agonist (monascin) attenuates the toxicity of methylglyoxal and hyperglycemia. 23954466

2013
Entrez Id: 10116
Gene Symbol: FEM1B
FEM1B
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.200 Biomarker MGD Abnormal glucose homeostasis and pancreatic islet function in mice with inactivation of the Fem1b gene. 16024793

2005
Entrez Id: 51167
Gene Symbol: CYB5R4
CYB5R4
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.210 Biomarker MGD Absence of a reductase, NCB5OR, causes insulin-deficient diabetes. 15247412

2004
Entrez Id: 9241
Gene Symbol: NOG
NOG
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.210 Biomarker RGD Activation of vascular bone morphogenetic protein signaling in diabetes mellitus. 21193740

2011
Entrez Id: 5105
Gene Symbol: PCK1
PCK1
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.300 Biomarker RGD Acute and selective regulation of glyceroneogenesis and cytosolic phosphoenolpyruvate carboxykinase in adipose tissue by thiazolidinediones in type 2 diabetes. 17242918

2007
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.300 Biomarker RGD Adaptation to hypoxia in the diabetic rat kidney. 17914354

2008
Entrez Id: 2034
Gene Symbol: EPAS1
EPAS1
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.200 Biomarker RGD Adaptation to hypoxia in the diabetic rat kidney. 17914354

2008
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD Adipocyte Xbp1s overexpression drives uridine production and reduces obesity. 29551634

2018
Entrez Id: 6715
Gene Symbol: SRD5A1
SRD5A1
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.210 Biomarker RGD Adrenocortical insufficiency in Otsuka Long-Evans Tokushima Fatty rats, a type 2 diabetes mellitus model. 17884440

2007
Entrez Id: 5919
Gene Symbol: RARRES2
RARRES2
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.300 Biomarker RGD Aerobic exercise decreases chemerin/CMKLR1 in the serum and peripheral metabolic organs of obesity and diabetes rats by increasing PPARγ. 30873215

2019
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD Age-dependent changes in metabolism, contractile function, and ischemic sensitivity in hearts from db/db mice. 12540618

2003
Entrez Id: 5327
Gene Symbol: PLAT
PLAT
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.210 Biomarker RGD Age-related changes in coagulation, fibrinolysis, and platelet aggregation in male WBN/Kob rats. 10899350

2000
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.210 Biomarker RGD Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats. 10049703

1999
Entrez Id: 2697
Gene Symbol: GJA1
GJA1
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.210 Biomarker RGD Altered gap junctional communication and renal haemodynamics in Zucker fatty rat model of type 2 diabetes. 21573906

2011
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.700 Biomarker MGD Although homozygous IRS-2-deficient mice (IRS-2-/- mice) had a body weight similar to wild-type mice, they progressively developed type 2 diabetes at 10 weeks. 11078455

2000