Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.330 Biomarker CTD_mouse Deficiency of ataxia telangiectasia mutated kinase modulates cardiac remodeling following myocardial infarction: involvement in fibrosis and apoptosis. 24358288

2014

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.700 Biomarker RGD Molecular analysis of infarct tissue showed a four-fold increase in NOS3 expression in the MSC + Ox group compared with the MI group. 22012955

2012

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.700 Biomarker RGD Results showed reduced endothelial nitric oxide synthase (eNOS) protein expression in the MI group; increased iNOS activity in the HgCl<sub>2</sub>-MI group, although without enough magnitude to reverse the reduction in NO bioavailability; and increased phenylephrine response in the HgCl<sub>2</sub>-MI group due to an increase in ROS production, notably via xanthine oxidase (XO). 28980197

2018

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.670 Biomarker RGD Simvastatin ameliorates ventricular remodeling via the TGF‑β1 signaling pathway in rats following myocardial infarction. 27121011

2017

Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker RGD Impairment of cardiac function and remodeling induced by myocardial infarction in rats are attenuated by the nonpeptide angiotensin-(1-7) analog AVE 0991. 21167013

2012

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Therapeutic RGD Both ACE (P = 0.022) and ACE2 (P = 0.015) mRNA increased in the border/infarct area compared with the viable area at day 3 after MI. 15671045

2005

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker RGD Bone marrow mesenchymal stem cell transplantation combined with perindopril treatment attenuates infarction remodelling in a rat model of acute myocardial infarction. 16845718

2006

Entrez Id: 3690
Gene Symbol: ITGB3
ITGB3
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 SusceptibilityMutation RGD To determine whether the polymorphic dinucleotide repeats found in intron 4 of the endothelial cell nitric oxide synthase (ecNOS) gene and the platelet GPIIIa PLA(1)/A(2) polymorphism are associated with myocardial infarction (MI) and venous thromboembolism (VTE) in African Americans. 10531147

1999

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker RGD Evaluation of the anti-myocardial ischemia effect of individual and combined extracts of Panax notoginseng and Carthamus tinctorius in rats. 23237935

2013

Entrez Id: 3690
Gene Symbol: ITGB3
ITGB3
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 SusceptibilityMutation RGD The relationship between polymorphisms in the endothelial cell nitric oxide synthase gene and the platelet GPIIIa gene with myocardial infarction and venous thromboembolism in African Americans. 10531147

1999

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker RGD Delayed anesthetic preconditioning protects against myocardial infarction via activation of nuclear factor-κB and upregulation of autophagy. 23143013

2013

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Therapeutic RGD By day 28, increases in ACE (P = 0.005) and ACE2 (P = 0.006) mRNA were also seen in the viable myocardium of MI rats compared with myocardium of control rats. 15671045

2005

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker RGD Regulation of collagen degradation in the rat myocardium after infarction. 8531210

1996

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker RGD Tumour necrosis factor-α and its receptors in the beneficial effects of vagal stimulation after myocardial infarction in rats. 21362018

2011

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker RGD Effects of captopril and angiotensin II receptor blockers (AT1, AT2) on myocardial ischemia-reperfusion induced infarct size. 21975128

2011

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Therapeutic RGD MI also significantly increased ACE and angiotensin type 1 receptor levels but decreased ACE2 activity by 40% (control, 246.2±25.1; DIZE alone, 254.2±20.6; MI, 148.9±29.2; RFU/min), which was reversed by DIZE treatment. 23959549

2013

Entrez Id: 3690
Gene Symbol: ITGB3
ITGB3
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 SusceptibilityMutation RGD There was no association between the GPIIIa genotypes and either MI or VTE. 10531147

1999

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Therapeutic RGD Rats were killed at days 1, 3, and 28 after MI, or treated for 4 weeks with the ACE inhibitor ramipril (1 mg/kg). 15671045

2005

Entrez Id: 4878
Gene Symbol: NPPA
NPPA
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.550 Biomarker RGD SERCA2a gene down-regulation in the non-infarcted myocardium of rats with MI does not correlate with ANP gene up-regulation, suggesting that the two genes are not antithetically regulated. 16087130

2005

Entrez Id: 6285
Gene Symbol: S100B
S100B
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.540 Biomarker RGD In a rat model of myocardial infarction following coronary artery ligation, we demonstrate in periinfarct myocytes, upregulation of RAGE, induction of S100B, and release into plasma with consequent myocyte apoptosis. 19910580

2010

Entrez Id: 6285
Gene Symbol: S100B
S100B
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.540 Biomarker RGD These results suggest that interaction of RAGE and its ligand S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53 signaling. 19910580

2010

Entrez Id: 6285
Gene Symbol: S100B
S100B
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.540 Biomarker RGD Post-myocardial infarction ventricular remodeling is associated with the expression of a variety of factors including S100B that can potentially modulate myocyte apoptosis. 19910580

2010

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.530 Biomarker RGD Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted rat. 10773235

2000

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.530 Biomarker RGD ET(A)-receptor blockade prevents matrix metalloproteinase activation late postmyocardial infarction in the rat. 11179039

2001

Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.520 Therapeutic RGD Phosphate-buffered solution, Dex-PCL-HEMA/PNIPAAm hydrogel, HMGB1 in phosphate-buffered solution, or HMGB1 in hydrogel was injected into a peri-infarcted area of cardiac tissue immediately after MI. 23188125

2013