Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1277
Gene Symbol: COL1A1
COL1A1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Therapeutic RGD microRNA-29b Mediates the Antifibrotic Effect of Tanshinone IIA in Postinfarct Cardiac Remodeling. 25636075

2016

Entrez Id: 5902
Gene Symbol: RANBP1
RANBP1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD Nuclear pore rearrangements and nuclear trafficking in cardiomyocytes from rat and human failing hearts. 25341891

2015

Entrez Id: 2936
Gene Symbol: GSR
GSR
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Therapeutic RGD Myocardial infarction group receiving vehicle had significantly lower left ventricular developed and systolic pressures, rate of rise/decrease of left ventricular pressure, stroke volume, ejection fraction and cardiac output, and serum superoxide dismutase and glutathione reductase than those of sham group. 25119867

2015

Entrez Id: 2475
Gene Symbol: MTOR
MTOR
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Therapeutic RGD Thyroid hormone improves the mechanical performance of the post-infarcted diabetic myocardium: a response associated with up-regulation of Akt/mTOR and AMPK activation. 23773982

2014

Entrez Id: 4208
Gene Symbol: MEF2C
MEF2C
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Therapeutic RGD Phenanthrene exposure causes cardiac arrhythmia in embryonic zebrafish via perturbing calcium handling. 23948075

2014

Entrez Id: 2691
Gene Symbol: GHRH
GHRH
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Therapeutic RGD Synthesis of new potent agonistic analogs of growth hormone-releasing hormone (GHRH) and evaluation of their endocrine and cardiac activities. 24373935

2014

Entrez Id: 664
Gene Symbol: BNIP3
BNIP3
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD The key findings of the present study were: a) upregulation of autophagy-related genes (GABARAPL1, ATG7, BNIP3, CTSL1 and LAMP2) was observed only in plantaris while muscle atrophy was observed in both soleus and plantaris muscles, and b) Cathepsin L activity, Bnip3 and Fis1 protein levels, and levels of lipid hydroperoxides were increased specifically in plantaris muscle of MI rats. 24427319

2014

Entrez Id: 1072
Gene Symbol: CFL1
CFL1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Therapeutic RGD Membrane ERα attenuates myocardial fibrosis via RhoA/ROCK-mediated actin remodeling in ovariectomized female infarcted rats. 24292258

2014

Entrez Id: 51024
Gene Symbol: FIS1
FIS1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD The key findings of the present study were: a) upregulation of autophagy-related genes (GABARAPL1, ATG7, BNIP3, CTSL1 and LAMP2) was observed only in plantaris while muscle atrophy was observed in both soleus and plantaris muscles, and b) Cathepsin L activity, Bnip3 and Fis1 protein levels, and levels of lipid hydroperoxides were increased specifically in plantaris muscle of MI rats. 24427319

2014

Entrez Id: 10533
Gene Symbol: ATG7
ATG7
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD The key findings of the present study were: a) upregulation of autophagy-related genes (GABARAPL1, ATG7, BNIP3, CTSL1 and LAMP2) was observed only in plantaris while muscle atrophy was observed in both soleus and plantaris muscles, and b) Cathepsin L activity, Bnip3 and Fis1 protein levels, and levels of lipid hydroperoxides were increased specifically in plantaris muscle of MI rats. 24427319

2014

Entrez Id: 6910
Gene Symbol: TBX5
TBX5
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Therapeutic RGD Phenanthrene exposure causes cardiac arrhythmia in embryonic zebrafish via perturbing calcium handling. 23948075

2014

Entrez Id: 890
Gene Symbol: CCNA2
CCNA2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD Acute myocardial infarction induced functional cardiomyocytes to re-enter the cell cycle. 23634243

2013

Entrez Id: 3759
Gene Symbol: KCNJ2
KCNJ2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Therapeutic RGD Mesenchymal stem cell transplantation mitigates electrophysiological remodeling in a rat model of myocardial infarction. 23647964

2013

Entrez Id: 6590
Gene Symbol: SLPI
SLPI
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Therapeutic RGD Attenuation of increased secretory leukocyte protease inhibitor, matricellular proteins and angiotensin II and left ventricular remodeling by candesartan and omapatrilat during healing after reperfused myocardial infarction. 23361363

2013

Entrez Id: 4217
Gene Symbol: MAP3K5
MAP3K5
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Therapeutic RGD A small molecule inhibitor of ASK1 was shown for the first time to reduce apoptosis and myocardial infarct size in a rat model of ischemia/reperfusion. 22635076

2012

Entrez Id: 4217
Gene Symbol: MAP3K5
MAP3K5
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Therapeutic RGD We determined whether a small molecule inhibitor of apoptosis signal-regulating kinase 1 (ASK1-i) could reduce myocardial infarct size in a rat ischemia/reperfusion model. 22635076

2012

Entrez Id: 3776
Gene Symbol: KCNK2
KCNK2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD The aim of this study was to investigate changes in gene expression and electrophysiology of TREK-1 in the left ventricle in a MI model. 21683547

2012

Entrez Id: 80310
Gene Symbol: PDGFD
PDGFD
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD Platelet-derived growth factor involvement in myocardial remodeling following infarction. 21767547

2012

Entrez Id: 3776
Gene Symbol: KCNK2
KCNK2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD Current density of TREK-1 at IBR increased significantly in both epicardial and endocardial cells after MI (P<0.01). 21683547

2012

Entrez Id: 4217
Gene Symbol: MAP3K5
MAP3K5
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Therapeutic RGD ASK1-I and IPC significantly reduced myocardial infarct size (27.7% ± 3.3%, 16.5% ± 3.4%, and 41.5% ± 4.8% in the ASK1-i group, the IPC group, and the vehicle group, respectively; P = 0.0002) and apoptosis (the percentage of apoptotic nuclei averaged 11.6% ± 1.0%, 10.2% ± 1.7%, and 17.7% ± 2.0% in the ASK1-i group, IPC group, and vehicle group, respectively, P = 0.0055). 22635076

2012

Entrez Id: 203
Gene Symbol: AK1
AK1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Therapeutic RGD In proteomic analysis, the MI group showed decreased expression of adenylate kinase 1 (AK1) and mitochondrial NADP⁺-dependent isocitrate dehydrogenase (IDPm) after MI compared with the sham group. 22229508

2012

Entrez Id: 3776
Gene Symbol: KCNK2
KCNK2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD TREK-1 mRNA expression decreased significantly in both endocardial and epicardial cells in the infarct region after MI. 21683547

2012

Entrez Id: 3776
Gene Symbol: KCNK2
KCNK2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD Regional differential expression of TREK-1 at left ventricle in myocardial infarction. 21683547

2012

Entrez Id: 3776
Gene Symbol: KCNK2
KCNK2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD These results suggest that TREK-1 may participate in pathophysiologic alteration and electrical remodelling of left ventricular myocardium after MI, which may eventually lead to post-MI ventricular arrhythmias. 21683547

2012

Entrez Id: 1601
Gene Symbol: DAB2
DAB2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD miR-145 is differentially regulated by TGF-β1 and ischaemia and targets Disabled-2 expression and wnt/β-catenin activity. 21762377

2012