Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2936
Gene Symbol: GSR
GSR
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Therapeutic RGD Myocardial infarction group receiving vehicle had significantly lower left ventricular developed and systolic pressures, rate of rise/decrease of left ventricular pressure, stroke volume, ejection fraction and cardiac output, and serum superoxide dismutase and glutathione reductase than those of sham group. 25119867

2015

Entrez Id: 4192
Gene Symbol: MDK
MDK
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.210 Biomarker RGD Myocardial infarction induces expression of midkine, a heparin-binding growth factor with reparative activity. 9568069

1998

Entrez Id: 1909
Gene Symbol: EDNRA
EDNRA
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.230 Biomarker RGD Endothelin-1 receptor subtypes expression and binding in a perfused rat model of myocardial infarction. 12524016

2003

Entrez Id: 8654
Gene Symbol: PDE5A
PDE5A
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.250 Biomarker RGD Phosphodiesterase 5A inhibition induces Na+/H+ exchanger blockade and protection against myocardial infarction. 17339532

2007

Entrez Id: 57817
Gene Symbol: HAMP
HAMP
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.210 Biomarker RGD Hepcidin is strongly induced in cardiomyocytes under myocarditis and MI, conditions in which inflammatory cytokine levels increase and may play an important role in iron homeostasis and free radical generation. 19615879

2010

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker RGD Tumour necrosis factor-α and its receptors in the beneficial effects of vagal stimulation after myocardial infarction in rats. 21362018

2011

Entrez Id: 3776
Gene Symbol: KCNK2
KCNK2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.210 Biomarker RGD TREK-1 demonstrates specific changes in expression and electrophysiological function in left ventricle post MI. 21683547

2012

Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Therapeutic RGD HMGB1 injection with Dex-PCL-HEMA/PNIPAAm hydrogel attenuates cardiac remodeling and improves cardiac function after MI by inducing myocardial regeneration. 23188125

2013

Entrez Id: 2535
Gene Symbol: FZD2
FZD2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD A homologue of Drosophila tissue polarity gene frizzled is expressed in migrating myofibroblasts in the infarcted rat heart. 9142123

1997

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.290 Therapeutic RGD A novel Danshensu derivative confers cardioprotection via PI3K/Akt and Nrf2 pathways. 23290949

2013

Entrez Id: 4792
Gene Symbol: NFKBIA
NFKBIA
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.220 Therapeutic RGD A novel peptide ghrelin inhibits neural remodeling after myocardial infarction in rats. 19616538

2009

Entrez Id: 4217
Gene Symbol: MAP3K5
MAP3K5
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Therapeutic RGD A small molecule inhibitor of ASK1 was shown for the first time to reduce apoptosis and myocardial infarct size in a rat model of ischemia/reperfusion. 22635076

2012

Entrez Id: 4985
Gene Symbol: OPRD1
OPRD1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD Activation of peripheral delta opioid receptors eliminates cardiac electrical instability in a rat model of post-infarction cardiosclerosis via mitochondrial ATP-dependent K+ channels. 12798419

2003

Entrez Id: 890
Gene Symbol: CCNA2
CCNA2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD Acute myocardial infarction induced functional cardiomyocytes to re-enter the cell cycle. 23634243

2013

Entrez Id: 836
Gene Symbol: CASP3
CASP3
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Therapeutic RGD Ad-HGF improves the cardiac remodeling of rat following myocardial infarction by upregulating autophagy and necroptosis and inhibiting apoptosis. 27904666

2016

Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Biomarker RGD Alterations in sarcoplasmic reticulum and angiotensin II type 1 receptor gene expression after myocardial infarction in rats. 9652322

1998

Entrez Id: 332
Gene Symbol: BIRC5
BIRC5
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD Angiogenic signal triggered by ischemic stress induces myocardial repair in rat during chronic infarction. 15081314

2004

Entrez Id: 718
Gene Symbol: C3
C3
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.250 Biomarker RGD Anti-ischemia/reperfusion of C1 inhibitor in myocardial cell injury via regulation of local myocardial C3 activity. 16996480

2006

Entrez Id: 1437
Gene Symbol: CSF2
CSF2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.230 Biomarker RGD Antibody to granulocyte macrophage colony-stimulating factor reduces the number of activated tissue macrophages and improves left ventricular function after myocardial infarction in a rat coronary artery ligation model. 21326109

2011

Entrez Id: 10111
Gene Symbol: RAD50
RAD50
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Therapeutic RGD Antibody-array technique reveals overexpression of important DNA-repair proteins during cardiac ischemic preconditioning. 15623426

2005

Entrez Id: 847
Gene Symbol: CAT
CAT
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.540 Biomarker RGD Antioxidant enzyme gene expression in congestive heart failure following myocardial infarction. 14575298

2003

Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.520 Biomarker RGD Antioxidant enzyme gene expression in congestive heart failure following myocardial infarction. 14575298

2003

Entrez Id: 513
Gene Symbol: ATP5F1D
ATP5F1D
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Therapeutic RGD Astragaloside IV protects heart from ischemia and reperfusion injury via energy regulation mechanisms. 23809007

2013

Entrez Id: 3605
Gene Symbol: IL17A
IL17A
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.260 Biomarker RGD At week 1, MI animals exhibited increased IL-6, IL-23 and TGF-β mRNA levels with no apparent change in IL-17 mRNA or protein levels in whole LV. 23096364

2012

Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Biomarker RGD Atorvastatin enhances interleukin-10 levels and improves cardiac function in rats after acute myocardial infarction. 18459941

2009