Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.250 Biomarker RGD Myocardial infarction increases ACE2 expression in rat and humans. 15671045

2005

Entrez Id: 2936
Gene Symbol: GSR
GSR
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Therapeutic RGD Myocardial infarction group receiving vehicle had significantly lower left ventricular developed and systolic pressures, rate of rise/decrease of left ventricular pressure, stroke volume, ejection fraction and cardiac output, and serum superoxide dismutase and glutathione reductase than those of sham group. 25119867

2015

Entrez Id: 4192
Gene Symbol: MDK
MDK
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.210 Biomarker RGD Myocardial infarction induces expression of midkine, a heparin-binding growth factor with reparative activity. 9568069

1998

Entrez Id: 3371
Gene Symbol: TNC
TNC
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.210 Biomarker RGD Tenascin-C modulates adhesion of cardiomyocytes to extracellular matrix during tissue remodeling after myocardial infarction. 11454990

2001

Entrez Id: 1909
Gene Symbol: EDNRA
EDNRA
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.210 Biomarker RGD Endothelin-1 receptor subtypes expression and binding in a perfused rat model of myocardial infarction. 12524016

2003

Entrez Id: 7057
Gene Symbol: THBS1
THBS1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.260 Biomarker RGD Thrombospondin-1 is induced in rat myocardial infarction and its induction is accelerated by ischemia/reperfusion. 16179730

2005

Entrez Id: 1462
Gene Symbol: VCAN
VCAN
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.210 Biomarker RGD Versican is induced in infiltrating monocytes in myocardial infarction. 16311904

2006

Entrez Id: 8654
Gene Symbol: PDE5A
PDE5A
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.220 Biomarker RGD Phosphodiesterase 5A inhibition induces Na+/H+ exchanger blockade and protection against myocardial infarction. 17339532

2007

Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Therapeutic RGD Monocyte chemoattractant protein-1 (MCP-1) is a key mediator of left ventricular (LV) remodeling during the early phase of myocardial infarction (MI). 18753699

2008

Entrez Id: 57817
Gene Symbol: HAMP
HAMP
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD Hepcidin is strongly induced in cardiomyocytes under myocarditis and MI, conditions in which inflammatory cytokine levels increase and may play an important role in iron homeostasis and free radical generation. 19615879

2010

Entrez Id: 1437
Gene Symbol: CSF2
CSF2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.220 Biomarker RGD Granulocyte macrophage colony-stimulating factor (GM-CSF) promotes infarct expansion and inappropriate collagen synthesis in a myocardial infarction (MI). 21326109

2011

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker RGD Tumour necrosis factor-α and its receptors in the beneficial effects of vagal stimulation after myocardial infarction in rats. 21362018

2011

Entrez Id: 3776
Gene Symbol: KCNK2
KCNK2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD TREK-1 mRNA expression decreased significantly in both endocardial and epicardial cells in the infarct region after MI. 21683547

2012

Entrez Id: 4217
Gene Symbol: MAP3K5
MAP3K5
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Therapeutic RGD ASK1-I and IPC significantly reduced myocardial infarct size (27.7% ± 3.3%, 16.5% ± 3.4%, and 41.5% ± 4.8% in the ASK1-i group, the IPC group, and the vehicle group, respectively; P = 0.0002) and apoptosis (the percentage of apoptotic nuclei averaged 11.6% ± 1.0%, 10.2% ± 1.7%, and 17.7% ± 2.0% in the ASK1-i group, IPC group, and vehicle group, respectively, P = 0.0055). 22635076

2012

Entrez Id: 3605
Gene Symbol: IL17A
IL17A
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.210 Biomarker RGD IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction. 23096364

2014

Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.520 Therapeutic RGD High-mobility group box 1 (HMGB1), a nuclear protein, has been recently reported to attenuate cardiac remodeling after myocardial infarction (MI). 23188125

2013

Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.520 Therapeutic RGD HMGB1 injection with Dex-PCL-HEMA/PNIPAAm hydrogel attenuates cardiac remodeling and improves cardiac function after MI by inducing myocardial regeneration. 23188125

2013

Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.250 Therapeutic RGD Angiotensin-converting enzyme 2 (ACE2) plays a critical role against myocardial infarction (MI). 23959549

2013

Entrez Id: 2535
Gene Symbol: FZD2
FZD2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD A homologue of Drosophila tissue polarity gene frizzled is expressed in migrating myofibroblasts in the infarcted rat heart. 9142123

1997

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.210 Therapeutic RGD A novel Danshensu derivative confers cardioprotection via PI3K/Akt and Nrf2 pathways. 23290949

2014

Entrez Id: 4792
Gene Symbol: NFKBIA
NFKBIA
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.220 Therapeutic RGD A novel peptide ghrelin inhibits neural remodeling after myocardial infarction in rats. 19616538

2010

Entrez Id: 9255
Gene Symbol: AIMP1
AIMP1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD A rat model of myocardial infarction was utilized to examine EMAP II distribution (in situ hybridization) and protein expression (Western analysis) over a 6-week period. 14732363

2004

Entrez Id: 4217
Gene Symbol: MAP3K5
MAP3K5
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Therapeutic RGD A small molecule inhibitor of ASK1 was shown for the first time to reduce apoptosis and myocardial infarct size in a rat model of ischemia/reperfusion. 22635076

2012

Entrez Id: 4985
Gene Symbol: OPRD1
OPRD1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD Activation of peripheral delta opioid receptors eliminates cardiac electrical instability in a rat model of post-infarction cardiosclerosis via mitochondrial ATP-dependent K+ channels. 12798419

2003

Entrez Id: 890
Gene Symbol: CCNA2
CCNA2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD Acute myocardial infarction induced functional cardiomyocytes to re-enter the cell cycle. 23634243

2013