Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Therapeutic RGD Both ACE (P = 0.022) and ACE2 (P = 0.015) mRNA increased in the border/infarct area compared with the viable area at day 3 after MI. 15671045

2005

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Therapeutic RGD By day 28, increases in ACE (P = 0.005) and ACE2 (P = 0.006) mRNA were also seen in the viable myocardium of MI rats compared with myocardium of control rats. 15671045

2005

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker RGD Effects of captopril and angiotensin II receptor blockers (AT1, AT2) on myocardial ischemia-reperfusion induced infarct size. 21975128

2011

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Therapeutic RGD MI also significantly increased ACE and angiotensin type 1 receptor levels but decreased ACE2 activity by 40% (control, 246.2±25.1; DIZE alone, 254.2±20.6; MI, 148.9±29.2; RFU/min), which was reversed by DIZE treatment. 23959549

2013

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Therapeutic RGD Rats were killed at days 1, 3, and 28 after MI, or treated for 4 weeks with the ACE inhibitor ramipril (1 mg/kg). 15671045

2005

Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.250 Biomarker RGD By day 28, increases in ACE (P = 0.005) and ACE2 (P = 0.006) mRNA were also seen in the viable myocardium of MI rats compared with myocardium of control rats. 15671045

2005

Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.250 Biomarker RGD Both ACE (P = 0.022) and ACE2 (P = 0.015) mRNA increased in the border/infarct area compared with the viable area at day 3 after MI. 15671045

2005

Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.250 Therapeutic RGD MI also significantly increased ACE and angiotensin type 1 receptor levels but decreased ACE2 activity by 40% (control, 246.2±25.1; DIZE alone, 254.2±20.6; MI, 148.9±29.2; RFU/min), which was reversed by DIZE treatment. 23959549

2013

Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.250 Biomarker RGD Myocardial infarction increases ACE2 expression in rat and humans. 15671045

2005

Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.250 Biomarker RGD The increase in ACE2 after MI suggests that it plays an important role in the negative modulation of the renin angiotensin system in the generation and degradation of angiotensin peptides after cardiac injury. 15671045

2005

Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.250 Therapeutic RGD Angiotensin-converting enzyme 2 (ACE2) plays a critical role against myocardial infarction (MI). 23959549

2013

Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.250 Biomarker RGD In contrast, ramipril had no effect on cardiac ACE2 mRNA, which remained elevated in all areas of the MI rat heart. 15671045

2005

Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.250 Biomarker RGD We studied the expression of ACE2 after myocardial infarction (MI) in the rat as well as in human failing hearts. 15671045

2005

Entrez Id: 9510
Gene Symbol: ADAMTS1
ADAMTS1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.220 Biomarker RGD In situ hybridization revealed strong ADAMTS1 mRNA signals in the endothelium and myocardium in the infarcted heart, mainly in the infarct zone, at 3 h after myocardial infarction. 15625312

2005

Entrez Id: 9510
Gene Symbol: ADAMTS1
ADAMTS1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.220 Biomarker RGD To test the hypothesis that ADAMTS1 appears in infarcted myocardial tissue, we examined ADAMTS1 mRNA expression in a rat myocardial infarction model by Northern blotting, real-time RT-PCR and in situ hybridization. 15625312

2005

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 ModifyingMutation RGD Changes in adiponectin expression in acute myocardial infarction rats and the significance of bisoprolol intervention. 21326342

2011

Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.240 Biomarker RGD Specific beta1-adrenergic receptor silencing with small interfering RNA lowers high blood pressure and improves cardiac function in myocardial ischemia. 17143192

2007

Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Biomarker RGD Potent adenylate cyclase agonist forskolin restores myoprotective effects of ischemic preconditioning in rat hearts after myocardial infarction. 12400771

2002

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.240 Biomarker RGD In a rat model of myocardial infarction following coronary artery ligation, we demonstrate in periinfarct myocytes, upregulation of RAGE, induction of S100B, and release into plasma with consequent myocyte apoptosis. 19910580

2010

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.240 Biomarker RGD These results suggest that interaction of RAGE and its ligand S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53 signaling. 19910580

2010

Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker RGD Impairment of cardiac function and remodeling induced by myocardial infarction in rats are attenuated by the nonpeptide angiotensin-(1-7) analog AVE 0991. 21167013

2012

Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Biomarker RGD The purpose of this study was to investigate the function of sarcoplasmic reticulum (SR) and the role of angiotensin II type 1 receptor (AT1) in ventricular remodeling in non-infarcted areas after myocardial infarction (MI). 9652322

1998

Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Biomarker RGD Alterations in sarcoplasmic reticulum and angiotensin II type 1 receptor gene expression after myocardial infarction in rats. 9652322

1998

Entrez Id: 9255
Gene Symbol: AIMP1
AIMP1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD Six weeks following myocardial infarction, EMAP II protein is elevated above control, changes its location of transcription from the inflammatory cell population to that of the fibroblasts located in the relative avascular scar tissue, and has resumed its perivascular stromal distribution in the viable periinfarct tissue. 14732363

2004

Entrez Id: 9255
Gene Symbol: AIMP1
AIMP1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD A rat model of myocardial infarction was utilized to examine EMAP II distribution (in situ hybridization) and protein expression (Western analysis) over a 6-week period. 14732363

2004