Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.300 Biomarker PSYGENET Effects of chemokine receptor signalling on cognition-like, emotion-like and sociability behaviours of CCR6 and CCR7 knockout mice. 24333375

2014

Entrez Id: 5309
Gene Symbol: PITX3
PITX3
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.300 Biomarker PSYGENET Pitx3 deficient mice as a genetic animal model of co-morbid depressive disorder and parkinsonism. 24480473

2014

Entrez Id: 1235
Gene Symbol: CCR6
CCR6
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.300 Biomarker PSYGENET Effects of chemokine receptor signalling on cognition-like, emotion-like and sociability behaviours of CCR6 and CCR7 knockout mice. 24333375

2014

Entrez Id: 4160
Gene Symbol: MC4R
MC4R
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.300 Biomarker PSYGENET Anhedonia requires MC4R-mediated synaptic adaptations in nucleus accumbens. 22785313

2012

Entrez Id: 1395
Gene Symbol: CRHR2
CRHR2
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.300 Biomarker PSYGENET CRF2 receptor-deficiency eliminates opiate withdrawal distress without impairing stress coping. 21946917

2012

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.300 Biomarker PSYGENET Perception of a naturalistic stressor interacts with 5-HTTLPR/rs25531 genotype and gender to impact reward responsiveness. 22094432

2012

Entrez Id: 5594
Gene Symbol: MAPK1
MAPK1
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.300 Biomarker PSYGENET Extracellular signal-regulated kinase 2 signaling in the hippocampal dentate gyrus mediates the antidepressant effects of testosterone. 22265242

2012

Entrez Id: 2697
Gene Symbol: GJA1
GJA1
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.300 Biomarker PSYGENET Gap junction dysfunction in the prefrontal cortex induces depressive-like behaviors in rats. 22189291

2012

Entrez Id: 478
Gene Symbol: ATP1A3
ATP1A3
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.300 Biomarker PSYGENET Decreased neuronal Na+, K+ -ATPase activity in Atp1a3 heterozygous mice increases susceptibility to depression-like endophenotypes by chronic variable stress. 21418141

2011

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.300 Biomarker PSYGENET Retinoid x receptor gamma control of affective behaviors involves dopaminergic signaling in mice. 20620876

2010

Entrez Id: 6507
Gene Symbol: SLC1A3
SLC1A3
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.300 Biomarker PSYGENET Increased vulnerability to depressive-like behavior of mice with decreased expression of VGLUT1. 19409534

2009

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.300 Biomarker PSYGENET Animal models of depression in dopamine, serotonin, and norepinephrine transporter knockout mice: prominent effects of dopamine transporter deletions. 18690111

2008

Entrez Id: 3620
Gene Symbol: IDO1
IDO1
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.310 Biomarker PSYGENET Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression. 22751107

2012

Entrez Id: 57030
Gene Symbol: SLC17A7
SLC17A7
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.310 Biomarker PSYGENET Chronic social defeat stress model: behavioral features, antidepressant action, and interaction with biological risk factors. 22707231

2012

Entrez Id: 288
Gene Symbol: ANK3
ANK3
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.310 Biomarker PSYGENET The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy males. 21676128

2011

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.310 Biomarker PSYGENET Corticotropin-releasing hormone receptor type 1 (CRHR1) genetic variation and stress interact to influence reward learning. 21917807

2011

Entrez Id: 3776
Gene Symbol: KCNK2
KCNK2
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.310 Biomarker PSYGENET Variation in TREK1 gene linked to depression-resistant phenotype is associated with potentiated neural responses to rewards in humans. 19621370

2010

Entrez Id: 9869
Gene Symbol: SETDB1
SETDB1
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.310 Biomarker PSYGENET Setdb1 histone methyltransferase regulates mood-related behaviors and expression of the NMDA receptor subunit NR2B. 20505083

2010

Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.310 Biomarker PSYGENET Decreased expression of serotonin 1A receptor in the dentate gyrus in association with chronic mild stress: a rat model of post-stroke depression. 19896211

2009

Entrez Id: 57030
Gene Symbol: SLC17A7
SLC17A7
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.310 Biomarker PSYGENET Increased vulnerability to depressive-like behavior of mice with decreased expression of VGLUT1. 19409534

2009

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.310 Biomarker PSYGENET Anhedonia as a phenotype for the Val158Met COMT polymorphism in relatives of patients with schizophrenia. 19025226

2008

Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.310 Biomarker PSYGENET Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans. 17675407

2007

Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.320 Biomarker PSYGENET CACNA1C risk variant affects reward responsiveness in healthy individuals. 25290268

2014

Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.320 Biomarker PSYGENET The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy males. 21676128

2011

Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.320 Biomarker PSYGENET Animal models of depression in dopamine, serotonin, and norepinephrine transporter knockout mice: prominent effects of dopamine transporter deletions. 18690111

2008