Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0024668
Disease: Mammary Neoplasms, Experimental
Mammary Neoplasms, Experimental 		0.500 Biomarker RGD Steroid hormone receptor expression and proliferation in rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. 15637090

2005
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.300 Biomarker RGD Soy isoflavones modulate azoxymethane-induced rat colon carcinogenesis exposed pre- and postnatally and inhibit growth of DLD-1 human colon adenocarcinoma cells by increasing the expression of estrogen receptor-beta. 19141699

2009
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.300 Biomarker RGD Estrogen receptor-β in the paraventricular nucleus and rostroventrolateral medulla plays an essential protective role in aldosterone/salt-induced hypertension in female rats. 23608653

2013
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0028754
Disease: Obesity
Obesity 		0.300 Biomarker RGD Impact of estradiol, ER subtype specific agonists and genistein on energy homeostasis in a rat model of nutrition induced obesity. 22230815

2012
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.250 Biomarker RGD However, ERB-041 has a dramatic beneficial effect in the HLA-B27 transgenic rat model of inflammatory bowel disease and the Lewis rat adjuvant-induced arthritis model. 14500559

2003
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0004096
Disease: Asthma
Asthma 		0.240 Biomarker RGD ERB-041 [7-ethenyl-2-(3-fluoro-4-hydroxyphenyl)-1,3-benzoxazol-5-ol], an ERbeta agonist, was profiled on cytokine release from interleukin-1beta-stimulated human airway smooth muscle (HASM) cells and in the rodent asthma model. 18375789

2008
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0009319
Disease: Colitis
Colitis 		0.230 Biomarker RGD Estrogen receptor-β signaling modulates epithelial barrier function. 21252046

2011
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0521170
Disease: Osteoporotic Fractures
Osteoporotic Fractures 		0.220 Biomarker RGD Callus formation is related to the expression ratios of estrogen receptors-alpha and -beta in ovariectomy-induced osteoporotic fracture healing. 25085540

2014
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia 		0.210 Biomarker RGD Estradiol modulates bcl-2 in cerebral ischemia: a potential role for estrogen receptors. 10414967

1999
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack 		0.200 Biomarker RGD Periodic 17β-estradiol pretreatment protects rat brain from cerebral ischemic damage via estrogen receptor-β. 23593292

2013
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0010692
Disease: Cystitis
Cystitis 		0.200 Biomarker RGD The effect of tamoxifen on bladder functions and histology, and the role of estrogen receptor beta in a rat chemical cystitis model. 16894621

2007
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.200 Biomarker RGD An estrogen receptor-beta agonist is active in models of inflammatory and chemical-induced pain. 17056036

2006
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension 		0.200 Biomarker RGD Estrogen rescues preexisting severe pulmonary hypertension in rats. 21700911

2011
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0036982
Disease: Shock, Hemorrhagic
Shock, Hemorrhagic 		0.200 Biomarker RGD Upregulation of mitochondrial respiratory complex IV by estrogen receptor-beta is critical for inhibiting mitochondrial apoptotic signaling and restoring cardiac functions following trauma-hemorrhage. 16859701

2006
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0243026
Disease: Sepsis
Sepsis 		0.200 Biomarker RGD To determine the effect of an estrogen receptor-beta selective agent in experimental models of systemic infection and sepsis. 16755255

2006
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0273115
Disease: Lung Injury
Lung Injury 		0.200 Biomarker RGD Estrogen receptor hormone agonists limit trauma hemorrhage shock-induced gut and lung injury in rats. 20195535

2010
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.600 Therapeutic RGD Diffusion weighted imaging evaluated the early therapy effect of tamoxifen in an MNU-induced mammary cancer rat model. 23700476

2013
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0024668
Disease: Mammary Neoplasms, Experimental
Mammary Neoplasms, Experimental 		0.500 Therapeutic RGD Simultaneous disruption of estrogen receptor and Wnt/β-catenin signaling is involved in methyl amooranin-mediated chemoprevention of mammary gland carcinogenesis in rats. 24078029

2013
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.400 Therapeutic RGD [The expression of estrogen receptor alpha and beta in the intervention of different estrogens in rat bone metabolism]. 16955786

2006
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.250 Therapeutic RGD Estrogen receptor β and oxytocin interact to modulate anxiety-like behavior and neuroendocrine stress reactivity in adult male and female rats. 24631553

2014
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.250 Therapeutic RGD Chaihu-Shugan-San administration ameliorates perimenopausal anxiety and depression in rats. 24015243

2013
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.250 Therapeutic RGD Estradiol decreases rat depressive behavior by estrogen receptor beta but not alpha: no correlation with plasma corticosterone. 24128867

2014
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.230 Therapeutic RGD Impact of estrogen receptor beta activation on functional recovery after experimental stroke. 24406718

2014
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0600142
Disease: Hot flushes
Hot flushes 		0.220 Therapeutic RGD Novel ligands balance estrogen receptor β and α agonism for safe and effective suppression of the vasomotor response in the ovariectomized female rat model of menopause. 24823389

2014
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0029823
Disease: Other specified peritonitis
Other specified peritonitis 		0.200 Therapeutic RGD Estradiol receptors agonists induced effects in rat intestinal microcirculation during sepsis. 23063870

2013