Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0003130
Disease: Anoxia
Anoxia
0.030 AlteredExpression LHGDN Cyclooxygenase-2 and presenilin-1 gene expression induced by interleukin-1beta and amyloid beta 42 peptide is potentiated by hypoxia in primary human neural cells. 12050157

2002

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0003130
Disease: Anoxia
Anoxia
0.030 AlteredExpression LHGDN PGI(2), but not TXA(2) synthesis, was absolutely dependent on upregulation of COX-2 by hypoxia. 17046322

2006

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0003130
Disease: Anoxia
Anoxia
0.030 AlteredExpression LHGDN These data demonstrate that PGE(2) production via COX-2-catalyzed pathway plays a critical role in HIF-1alpha regulation by hypoxia and imply that COX-2 inhibitors can prevent hypoxic induction of HIF-mediated gene transcription in cancer cells. 12401798

2002