Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder
0.310 Biomarker PSYGENET Genetics of circadian rhythms and mood spectrum disorders. 21835597

2011

Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder
0.310 Biomarker PSYGENET The role of circadian clock genes in mental disorders. 17969870

2007

Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder
0.310 Biomarker PSYGENET (1) A subgroup of depressed patients have documented circadian abnormalities in mood, sleep, temperature and neuroendocrine secretion; (2) It is also suggested that seasonal affective disorder (SAD) patients may show an abnormality in their ability to shift their daily circadian rhythms in response to seasonal light changes; (3) The dramatic improvements in some depressions in response to three treatment modalities which manipulate circadian rhythms suggest that circadian abnormalities reported in patients may constitute a core component of the pathophysiology in depression; (4) Mutations in clock genes have been discovered that accelerate or delay circadian cycles; (5) It is hypothesized that 24-hour rhythm abnormalities in major depression and SAD may be due to altered clock genes. 10700653

2000