Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN [Clinicopathologic significance of cyclooxygenase-2 mRNA expression in human breast carcinoma]. 12667327

2002
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN The clear relationship between HER-2/neu status and COX-2 expression in human breast tumors suggests that this mechanism is likely to be operative in vivo. 11901151

2002
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Correlation of COX-2 and Ep-CAM overexpression in human invasive breast cancer and its impact on survival. 12592372

2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Overexpression of cyclooxygenase-2 is associated with breast carcinoma and its poor prognostic factors. 14681319

2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program. 15050918

2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker LHGDN Role of COX-2, VEGF and cyclin D1 in mammary infiltrating duct carcinoma. 12883688

2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Expression of the ELAV-like protein HuR is associated with higher tumor grade and increased cyclooxygenase-2 expression in human breast carcinoma. 15328200

2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Elevated cyclooxygenase-2 expression correlates with distant metastases in breast cancer. 15330183

2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN COX-2 expression is associated with an aggressive phenotype in ductal carcinoma in situ. 14735188

2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN COX-2 may be directly involved with mammary carcinogenesis, since expression of COX-2 is sufficient for formation of breast tumors in transgenic mice, and COX-2 selective inhibitors can suppress tumorigenesis in rodent models of breast cancer. 15754118

2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker LHGDN Relationship between the expression of cyclooxygenase 2 and MDR1/P-glycoprotein in invasive breast cancers and their prognostic significance. 16168133

2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN COX-2 overexpression increases motility and invasion of breast cancer cells. 15809733

2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Similarly, we identified vascular channels in high-grade invasive ductal carcinoma of the breast over-expressing COX-2, but not in low-grade breast tumors. 17156488

2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Possible predictive markers related to micro-metastasis in breast cancer patients. 16596190

2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker LHGDN NFAT induces breast cancer cell invasion by promoting the induction of cyclooxygenase-2. 16505480

2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 GeneticVariation LHGDN The cyclooxygenase-2 (PTGS2) 8473T>C polymorphism is associated with breast cancer risk. 16489098

2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker LHGDN Discoidin domain receptor 1 receptor tyrosine kinase induces cyclooxygenase-2 and promotes chemoresistance through nuclear factor-kappaB pathway activation. 16912190

2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker LHGDN Cyclooxygenase-2 uses the protein kinase C/ interleukin-8/urokinase-type plasminogen activator pathway to increase the invasiveness of breast cancer cells. 17332916

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 GeneticVariation LHGDN Functional polymorphisms in the cyclooxygenase 2 (COX-2) gene and risk of breast cancer in a Chinese population. 17479405

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 GeneticVariation LHGDN A polymorphism in the 3' untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk: a nested case-control study. 17214885

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN COX-2 expression in lobular in situ neoplasia of the breast: correlation with histopathological grading system according to the Tavassoli classification. 17542993

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Expression of cyclooxygenase-2 and 12-lipoxygenase in human breast cancer and their relationship with HER-2/neu and hormonal receptors: impact on prognosis and therapy. 17192687

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Cyclooxygenase-2 expression during immortalization and breast cancer progression. 18199541

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Coexpression of VEGF-C and COX-2 and its association with lymphangiogenesis in human breast cancer. 18190720

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker LHGDN The malignant phenotype of breast cancer cells is reduced by COX-2 silencing. 18953425

2008