Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.400 Biomarker PSYGENET Alcohol dependence is associated with increased corticotropin releasing factor (CRF) influence on CeA GABA release and CRF type 1 receptor (CRF(1)) antagonists prevent the excessive alcohol consumption associated with dependence. 23220399

2013

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.360 Biomarker PSYGENET Corticotropin-releasing factor receptor antagonists in affective disorders and drug dependence-- an update. 16611089

2006

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Allelic variants of the glucocorticoid receptor (GR) gene contribute significantly to both cortisol levels and to measures of psychosis; corticotropin-releasing hormone receptor 1 variants contribute to measures of depression and psychosis. 24933348

2015

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker PSYGENET Allelic variants of the glucocorticoid receptor (GR) gene contribute significantly to both cortisol levels and to measures of psychosis; corticotropin-releasing hormone receptor 1 variants contribute to measures of depression and psychosis. 24933348

2015

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.330 Biomarker PSYGENET Association between functional polymorphism of the AVPR1b gene and polymorphism rs1293651 of the CRHR1 gene and bipolar disorder with psychotic features. 22341483

2012

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.360 Biomarker PSYGENET Association of CRHR1 and CRHR2 with major depressive disorder and panic disorder in a Japanese population. 22467522

2012

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.310 Biomarker PSYGENET Corticotropin-releasing hormone receptor type 1 (CRHR1) genetic variation and stress interact to influence reward learning. 21917807

2011

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.360 Biomarker PSYGENET Deficient beta-arrestin-2-CRF(1) receptor interactions could contribute to the pathophysiology of affective disorders by inducing excessive CRF(1) receptor signaling. 17363685

2007

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.360 Biomarker PSYGENET Epistatic interaction between CRHR1 and AVPR1b variants as a predictor of major depressive disorder. 23962971

2013

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Genetic moderation of child maltreatment effects on depression and internalizing symptoms by serotonin transporter linked polymorphic region (5-HTTLPR), brain-derived neurotrophic factor (BDNF), norepinephrine transporter (NET), and corticotropin releasing hormone receptor 1 (CRHR1) genes in African American children. 25422957

2014

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker PSYGENET Genetic moderation of child maltreatment effects on depression and internalizing symptoms by serotonin transporter linked polymorphic region (5-HTTLPR), brain-derived neurotrophic factor (BDNF), norepinephrine transporter (NET), and corticotropin releasing hormone receptor 1 (CRHR1) genes in African American children. 25422957

2014

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.360 Biomarker PSYGENET Genetic risk factors for depression in Alzheimer`s disease patients. 23157339

2013

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Histone modifications of the Crhr1 gene in a rat model of depression following chronic stress. 24867333

2014

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker PSYGENET Histone modifications of the Crhr1 gene in a rat model of depression following chronic stress. 24867333

2014

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.320 Biomarker PSYGENET In addition, GR and corticotropin-releasing hormone receptor 1 (CRHR1) genotypes contributed significantly to psychosis measures and CRHR1 contributed significantly to depression severity rating. 24166410

2014

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.320 Biomarker PSYGENET In addition, GR and corticotropin-releasing hormone receptor 1 (CRHR1) genotypes contributed significantly to psychosis measures and CRHR1 contributed significantly to depression severity rating. 24166410

2014

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.360 Biomarker PSYGENET Negative life events and corticotropin-releasing-hormone receptor1 gene in recurrent major depressive disorder. 23529111

2013

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.330 Biomarker PSYGENET No association between polymorphisms and haplotypes of the AVPR1b, CRHR1 and NR3C1 genes and depression with melancholic features in the course of bipolar disorder. 23068076

2013

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.400 Biomarker PSYGENET Ongoing clinical trials with pexacerfont and verucerfont in moderately to highly severe dependent anxious alcoholics may yield insight as to the role of CRF(1) receptor antagonists in a personalized medicine approach to treat drug or alcohol dependence. 23294766

2013

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET Only rs4792888 in CRHR1 showed modest evidence of association with duloxetine response in MDD (P=0.029 in GAD, P=0.054 in MDD). 22249355

2013

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.360 Biomarker PSYGENET Our results suggest possible involvement of the AVPR1b and CRHR1 genes in the ethiology of psychotic features in the course of affective disorders, and possible involvement of CRHR1 gene in the ethiology of bipolar disorder. 24012103

2013

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.330 Biomarker PSYGENET Our results suggest possible involvement of the AVPR1b and CRHR1 genes in the ethiology of psychotic features in the course of affective disorders, and possible involvement of CRHR1 gene in the ethiology of bipolar disorder. 24012103

2013

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.360 Biomarker PSYGENET Pharmacogenetic investigation of response to duloxetine treatment in generalized anxiety disorder. 22249355

2013

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.360 Biomarker PSYGENET Polymorphisms of CRHR1 and AVPR1b may modify susceptibility to mood disorders. 23962971

2013

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Previous research supports gene-environment interactions for polymorphisms in the corticotropin hormone receptor 1 gene (CRHR1) and the serotonin transporter gene linked polymorphic region (5-HTTLPR) in predicting depression, but it has rarely considered genetic influences on stress sensitization processes, whereby early adversities (EA) increase depressive reactivity to proximal stressors later in life. 25422958

2014